以脊柱关节痛为首发症状的布氏杆菌病患者的血清学检测分析  

Serological Analysis of Brucellosis Patients with Spinal Joint Pain as the First Symptom

作　　者：赵士霞 赵士杰[2] ZHAO Shixia;ZHAO Shijie(Department of clinical laboratory,Datong Hui Tu autonomous county center for disease control and prevention,Xining,Qinghai 810100;Department of clinical laboratory,Qinghai provincial people's hospital)

机构地区：[1]青海省西宁市大通回族土族自治县疾病预防控制中心检验科,青海西宁810100 [2]青海省人民医院检验科

出　　处：《中国伤残医学》2024年第11期1-4,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨与分析以脊柱关节痛为首发症状的布氏杆菌病患者的血清学检测价值.方法:选择2020年4月—2023年2月青海省西宁市大通回族土族自治县疾病预防控制中心收治的86例布氏杆菌病患者作为研究对象,其中以脊柱关节痛为首发症状的36例患者为关节痛组,非以脊柱关节痛为首发症状的50例患者为对照组,检测2组的血清学指标,判定患者的脊柱关节疼痛情况并进行相关性分析.结果:2组的白细胞、红细胞、血红蛋白、血小板计数等对比,组间差异无统计学意义(P>0.05).关节痛组的血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3含量均高于对照组,血清1,25-二羟基维生素D3含量均低于对照组,差异有统计学意义(P<0.05).关节痛组的脊柱关节疼痛VAS评分明显高于对照组,差异均有统计学意义(P<0.05).在86例患者中,Pearson分析显示,血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3、1,25-二羟基维生素D3含量与脊柱关节视觉模拟量表(VAS)评分存在相关性,差异均有统计学意义(P<0.05).二元logistic回归分析显示,血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3、1,25-二羟基维生素D3含量为影响脊柱关节疼痛VAS评分的重要因素,差异均有统计学意义(P<0.05).结论:以脊柱关节痛为首发症状的布氏杆菌病患者比较常见,多表现为血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3含量增高与血清1,25-二羟基维生素D3含量降低,加强血清学检测具有重要的临床意义.Objective:To explore and analyze the value of serologic detection in brucellosis patients with spinal arthralgia as the first symptom.Methods:86 cases of brucellosis in Datong Hui Tu autonomous county center for disease control and prevention from April 2020 to February 2023 were selected as the research objects,among which 36 cases of patients with spinal joint pain as the first symptom were selected as the arthralgia group,and 50 cases of patients without spinal joint pain as the first symptom were selected as the control group.Serological indexes of the two groups were detected to determine the spinal joint pain of patients and conduct correlation analysis.Results:There were no significant differences in leukocyte,erythrocyte,hemoglobin and platelet count between 2 groups(P>0.05).The contents of anti-nuclear antibody,anti-keratin antibody,anti-synoviocyclic citrulline peptide antibody and matrix metalloproteinase-3 in arthralgia group were higher than those in control group,and the contents of 1,25-dihydroxyvitamin D3 in serum were lower than those in control group,with statistical significance(P<0.05).The spinal joint pain VAS score of the arthralgia group was significantly higher than that of the control group,and the differences were statistically significant(P<0.05).Among 86 patients,Pearson analysis showed that serum levels of anti-nuclear antibody,anti-keratin antibody,anti-synovial cyclocitcitine peptide antibody,matrix metalloproteinase-3,1,25-dihydroxyvitamin D3 were correlated with VAS scores of spinal joint pain,with statistical significance(P<0.05).Binary logistic regression analysis showed that serum levels of anti-nuclear antibody,anti-keratin antibody,anti-synovial ring citcitine peptide antibody,matrix metalloproteinase-3 and 1,25-dihydroxyvitamin D3 were important factors affecting the VAS score of spinal joint pain,and the differences were statistically significant(P<0.05).Conclusion:Brucellosis patients with spinal arthralgia as the first symptom are relatively common,most of which are manif

关 键 词：脊柱关节痛 首发症状 布氏杆菌病 抗核抗体 抗角蛋白抗体 抗滑膜环瓜氨酸肽抗体 

分 类 号：R446.11[医药卫生—诊断学]