柴术降脂胶囊治疗冠脉临界病变痰瘀互结证的临床研究  

Clinical study on Chaizhu Jiangzhi capsule in the treatment of coronary borderline lesions with intermingled phlegm-stasis blood syndrome

作　　者：侯雪梅[1] 陈思娟[1] 姚建明[1] HOU Xuemei;CHEN Sijuan;YAO Jianming(Department of Cardiology,Jinan Municipal Hospital of Traditional Chinese Medicine,Shandong,Jinan 250012,China)

机构地区：[1]山东省济南市中医医院心内科,250012

出　　处：《河北医药》2024年第17期2606-2609,共4页Hebei Medical Journal

基　　金：山东省中医药科技项目(编号:2021M122)。

摘　　要：目的研究柴术降脂胶囊治疗冠脉临界病变痰瘀互结证的临床效果。方法筛选2021年11月至2023年11月接受CT冠脉血管成像(CTA)诊断表明存在冠脉临界病变,并经中医辨证显示为痰瘀互结患者80例,随机数表法分成对照组和治疗组,每组40例。2组均予以基础治疗,治疗组在基础治疗上另增加柴术降脂胶囊,均治疗6个月,对比2组斑块相关指标、血脂疗效[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、极低密度脂蛋白(VLDL)]及炎性指标[超敏C反应蛋白(hs-CRP)]和中医症状疗效评分、证候积分,以及西雅图心绞痛证候积分情况[活动受限(PL)、疾病稳定状态(AS)、疾病发作情况(AF)、治疗满意度(TS)、疾病认识度(DP)]。结果治疗组的面积狭窄程度及直径狭窄程度明显低于对照组(P<0.05)。治疗组的TC、TG、LDL、VLDL及hs-CRP水平明显低于对照组,HDL水平高于对照组(P<0.05)。治疗组冠心病心绞痛的中医症状疗效及中医证候积分明显低于对照组(P<0.05)。治疗组的PL、AS、AF、TS及DP西雅图心绞痛量表证候积分均高于对照组(P<0.05)。结论柴术降脂胶囊治疗冠脉临界病变痰瘀互结证的临床效果较好,能明显改善患者的冠脉狭窄情况及临床症状,并可有效降低血脂水平,值得推广。Objective To study the clinical effect of Chaizhu Jiangzhi capsule in the treatment of coronary borderline lesions with intermingled phlegm-stasis blood syndrome.Methods Eighty patients with coronary borderline lesions of intermingled phlegm-stasis blood syndrome,who underwent coronary CT angiography(CTA)and diagnosed in our hospital from November 2021 to November 2023,were enrolled.The patients were divided into control group(n=40)and treatment group(n=40).All patients were given basic treatment,those in the treatment group were additionally given Chaizhu Jiangzhi capsule.After 6 months of treatment,the plaque-related indicators,blood lipid level and inflammatory indicators,traditional Chinese medicine(TCM)efficacy scores,syndrome scores,and Seattle Angina Questionnaire(SAQ)scores were compared between the two groups.Results The degree of area stenosis and diameter stenosis in treatment group was significantly lower than control group(P<0.05).The levels of total cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL),very low-density lipoprotein(VLDL),high-sensitivity C-reactive protein(Hs-CRP)in treatment group were significantly lower that those of the control group,but high-density lipoprotein(HDL)level was significantly higher(P<0.05).The efficacy score and syndrome scores of TCM were significant difference between the treatment group and the control group(P<0.05).The scores of SAQ(physical limitation[PL],angina stability[AS],angina frequency[AF],treatment satisfaction[TS]and disease perception[DP])in treatment group were significantly higher than control group(P<0.05).Conclusion The clinical effect of Chaizhu Jiangzhi capsule in the treatment of coronary borderline lesions with intermingled phlegm-stasis blood syndrome is better,which can significantly improve the coronary artery stenosis and clinical symptoms of patients,and effectively reduce the blood lipid level,which is worth popularizing.

关 键 词：柴术降脂胶囊 冠脉临界病变 痰瘀互结证 治疗结果 

分 类 号：R543.3[医药卫生—心血管疾病]