胰岛素样生长因子-1在糖尿病视网膜病变机制中的研究进展  

Research progress of insulin-like growth factor-1 in the mechanism of diabetic retinopathy

作　　者：张衡 潘佳玥 杨杨[1] ZHANG Heng;PAN Jiayue;YANG Yang(Department of Endocrinology,Tianyou Hospital Affiliated to Wuhan University of Science&Technology,Hubei,Wuhan 430000,China;不详)

机构地区：[1]武汉科技大学附属天佑医院内分泌科,武汉市430000 [2]武汉科技大学香涛学院

出　　处：《河北医药》2024年第17期2680-2685,共6页Hebei Medical Journal

基　　金：湖北省卫生健康委员会联合基金项目(编号:WJ2019H235)。

摘　　要：胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)是与胰岛素结构相似的多肽,参与细胞生长、分化、物质代谢和创伤修复等生理过程。IGF-1在血液中主要与胰岛素样生长因子结合蛋白-3(insulin-like growth factor binding protein-3,IGFBP-3)形成复合物,这种复合物能起到调节IGF-1生物活性和半衰期的作用。糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病常见的一种微血管并发症,影响视力甚至导致失明。IGF-1可能参与了DR的发生发展,本文对IGF-1及其在DR中的作用机制进展进行综述。Insulin like growth factor-1(IGF-1)is a peptide with a similar structure to insulin that participates in physiological processes like cell growth,differentiation,material metabolism,and wound repair.IGF-1 mainly forms complexes with insulin like growth factor binding protein-3(IGFBP-3)in the blood,and they regulate the biological activity and half-life of IGF-1.Diabetes retinopathy(DR)is a common microvascular complication of diabetes,which affects vision and even leads to blindness.A growing number of studies have suggested the involvement of IGF-1 in the occurrence and development of DR.This article reviewed the progress of IGF-1 in DR and its mechanism of action.

关 键 词：糖尿病视网膜病变 胰岛素样生长因子-1 血-视网膜屏障 血管内皮生长因子 糖尿病黄斑水肿 

分 类 号：R587.29[医药卫生—内分泌]