参苓白术散加味治疗学龄前儿童生长发育迟缓临床研究  

Clinical Study on Modified Shenling Baizhu San for Growth Retardation of Preschool Children

作　　者：王淑敏 叶海娅 孙建星 王运清 常春阳 WANG Shumin;YE Haiya;SUN Jianxing;WANG Yunqing;CHANG Chunyang(Department of Pediatrics,Anji County Hospital of Chinese Medicine,Anji Zhejiang 313300,China)

机构地区：[1]安吉县中医医院儿科,浙江安吉313300

出　　处：《新中医》2024年第17期7-11,共5页New Chinese Medicine

摘　　要：目的:观察参苓白术散加味治疗学龄前儿童生长发育迟缓的疗效。方法:选取82例生长发育迟缓患儿为研究对象,按随机数字表法分为观察组及对照组各41例。对照组给予营养补充及饮食指导等常规治疗,观察组在对照组基础上给予参苓白术散加味治疗。比较2组临床疗效及不良反应,比较2组治疗前后的中医证候积分,血清锌、血红蛋白、生长激素、胰岛素样生长因子-1水平变化。随访3个月,比较2组治疗前后体质量。结果:观察组总有效率95.12%,高于对照组75.61%(P<0.05)。治疗后,2组中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组血清锌、血红蛋白水平均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,2组血清生长激素、胰岛素样生长因子-1水平及体质量均升高(P<0.05),且观察组高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参苓白术散加味治疗学龄前儿童生长发育迟缓疗效确切,可提高临床疗效,调节机体内血清锌、血红蛋白表达,改善血清生长激素水平和食欲,且安全可靠。Objective:To observe the clinical effect of modified Shenling Baizhu San for growth retardation of preschool children.Methods:A total of 82 children with growth retardation were selected as the study subjects and divided into the observation group and the control group according to the random number table method,with 41 cases in each group.The control group was given conventional treatment such as nutrition supplementation and dietary guidance,and the observation group was additionally treated with modified Shenling Baizhu San based on the treatment of the control group.Clinical effects and adverse reactions were compared between the two groups.Changes in levels of serum zinc,hemoglobin,growth hormone,and insulin-like growth factor-1,as well as traditional Chinese medicine syndrome scores were compared between two groups before and after treatment.After a three-month follow-up,body mass was compared between two groups before and after treatment.Results:The total effective rate was 95.12%in the observation group,higher than that of 75.61%in the control group(P<0.05).After treatment,traditional Chinese medicine syndrome scores in the two groups were declined(P<0.05),and the traditional Chinese medicine syndrome scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum zinc and hemoglobin in the two groups were increased(P<0.05),and the two levels in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of serum growth hormone,and insulin-like growth factor-1,as well as body mass in the two groups were increased(P<0.05),and the levels of serum growth hormone,and insulin-like growth factor-1,as well as body mass in the observation group were higher than those in the control group(P<0.05).There was no significant difference being found in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Shenling Baizhu San has a definite curative effect in the treatment of growth retardation

关 键 词：生长发育迟缓 参苓白术散 血红蛋白 生长激素 中医证候积分 胰岛素样生长因子-1 

分 类 号：R723[医药卫生—儿科]