雷公藤多苷片辅助治疗寻常型银屑病血热证临床研究  

Clinical Study on Tripterygium Glycosides Tablets in Adjuvant Treatment of Psoriasis Vulgaris with Blood Heat Syndrome

作　　者：马琳 祝美洁 MA Lin;ZHU Meijie(Department of Dermatology,Quzhou People's Hospital,Quzhou Zhejiang 324000,China)

机构地区：[1]衢州市人民医院皮肤科,浙江衢州324000

出　　处：《新中医》2024年第17期93-97,共5页New Chinese Medicine

摘　　要：目的:观察雷公藤多苷片辅助治疗寻常型银屑病血热证的临床疗效。方法:按随机数字表法将82例血热证银屑病患者分为联合组和对照组各41例。对照组给予窄谱中波紫外线(NB-UVB)全身照射治疗,联合组在对照组基础上加用雷公藤多苷片治疗。比较2组治疗前后中医证候积分、皮损面积与严重程度指数量表(PASI)评分、生活质量指数量表(DLQI)评分、皮肤屏障功能、炎性因子,统计临床疗效及不良反应发生率。结果:联合组总有效率为90.24%,高于对照组73.17%(P<0.05)。治疗后,2组各项中医证候评分均较治疗前降低(P<0.05),且联合组各项中医证候评分低于对照组(P<0.05)。治疗后,2组PASI、DLQI评分较治疗前降低(P<0.05),且联合组PASI、DLQI评分低于对照组(P<0.05)。治疗后,2组角质层含水量、皮脂含量较治疗前增高,经表皮水分丢失率(TEWL)较治疗前降低(P<0.05);且联合组角质层含水量、皮脂含量高于对照组,TEWL低于对照组(P<0.05)。治疗后,2组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)水平较治疗前降低(P<0.05),且联合组血清TNF-α、IL-17水平低于对照组(P<0.05)。结论:雷公藤多苷片辅助治疗寻常型银屑病血热证患者疗效更佳,能降低皮损严重程度与炎症反应、调节皮肤屏障功能,提高生活质量,且安全性较高。Objective:To observe the clinical effect of Tripterygium Glycosides Tablets in adjuvant treatment of psoriasis vulgaris with blood heat syndrome.Methods:A total of 82 patients with psoriasis vulgaris with blood heat syndrome were divided into the combination group and the control group by random number table method,with 41 cases in each group.The control group was given whole-body irradiation therapy with narrow-band ultraviolet B(NB UVB),and the combination group was additionally treated with Tripterygium Glycosides Tablets based on the treatment of the control group.Traditional Chinese medicine syndrome scores,Psoriasis Area and Severity Index(PASI)scores,Dermatology Life Quality Index(DLQI)scores,skin barrier function,and inflammatory factors were compared between the two groups before and after treatment;clinical effects and the incidence of adverse reactions were counted.Results:The total effective rate was 90.24%in the combination group,higher than that of 73.17%in the control group(P<0.05).After treatment,each traditional Chinese medicine syndrome score in the two groups were decreased when compared with those before treatment(P<0.05),and each score in the combination group was lower than that in the control group(P<0.05).After treatment,the scores of PASI and DLQI in the two groups were declined when compared with those before treatment(P<0.05),and the scores of PASI and DLQI in the combination group were lower than those in the control group(P<0.05).After treatment,moisture content and sebum content of the stratum corneum in the two groups were increased,and transepidermal water loss rate(TEWL)was dropped when compared with that before treatment(P<0.05);moisture content and sebum content of the stratum corneum in the combination group were higher than those in the control group,and TEWL in the combination group was lower than that in the control group(P<0.05).After treatment,tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)in serum in the two groups were declined when compared with those before t

关 键 词：寻常型银屑病 血热证 雷公藤多苷片 皮肤屏障功能 炎症因子 生活质量 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]