中药干预巩膜重塑:TGF-β/BMP通路在改善近视中的研究进展  

Chinese Medicine Intervention in Scleral Remodeling:Research Progress of TGF-β/BMP Pathway in Myopia Improvement

作　　者：刁春贤 郭俊国 吴秋欣 张浩[1] 温莹[3] DIAO Chunxian;GUO Junguo;WU Qiuxin;ZHANG Hao;WEN Ying(Shandong University of Traditional Chinese Medicine,Jinan Shandong 250355,China;Shandong Institute of EyeDisease Prevention and Control/Shandong Key Laboratory for Eye Disease Prevention and Treatment of Integrated Chineseand Western Medicine,Jinan Shandong 250002,China;Affiliated Eye Hospital of SDUTCM,Jinan Shandong 250002,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东省眼病防治研究院/山东省中西医结合眼病防治重点实验室,山东济南250002 [3]山东中医药大学附属眼科医院,山东济南250002

出　　处：《新中医》2024年第17期190-195,共6页New Chinese Medicine

基　　金：国家自然科学基金项目(82104937);国家重点研发计划项目(2019YFC1710205)。

摘　　要：通过梳理中药对巩膜重塑的作用机制,探讨中药基于转化生长因子-β/骨形态发生蛋白(TGF-β/BMP)信号通路改善近视的研究进展。收集、整理具有数据支持中药影响巩膜重塑、延缓近视及其干预TGF-β/BMP信号通路的文献资料,概述了近视的流行病学、巩膜重塑在近视发展中的作用,以及TGF-β/BMP信号通路与近视的关系。阐述了中药治疗近视的作用机制和中药干预TGF-β/BMP信号通路在实验和临床研究中的效果。发现部分中药对TGF-β/BMP信号通路具有调控作用,通过影响巩膜重塑的过程减缓近视的进展。中药干预TGF-β/BMP信号通路在改善近视中具有重要前景,通过进一步优化治疗方案,有望为近视患者提供更有效、更安全的治疗选择。This study explores the progress of Chinese medicinals in improving myopia based on the transforming growth factor-β/bone morphogenetic protein(TGF-β/BMP)signaling pathway by analyzing the action mechanism of Chinese medicinals in scleral remodeling.Literature data supporting the effect of Chinese medicinals on sclera remodeling to delay myopia and its intervention in TGF-β/BMP signaling pathway are collected and collated.The epidemiology of myopia,the role of sclera remodeling in myopia development,and the relationship between TGF-β/BMP signaling pathway and myopia are summarized.The action mechanism of Chinese medicinals in treating myopia and the effects of Chinese medicine intervention in the TGF-β/BMP signaling pathway in experimental and clinical studies were elucidated.It was found that some Chinese medicinals have regulatory effects on TGF-β/BMP signaling pathway,slowing down the development of myopia by affecting the process of scleral remodeling.The intervention of Chinese medicinals in the TGF-β/BMP signaling pathway has significant prospects for the improvement of myopia.Through further optimization of treatment plans,it is expected to provide more effective and safer treatment options for patients with myopia.

关 键 词：近视 巩膜重塑 转化生长因子-β/骨形态发生蛋白信号通路 中药 

分 类 号：R276.7[医药卫生—中医五官科学] R778.11[医药卫生—中医学]