吴耀南教授经验方胃萎方在慢性萎缩性胃炎伴肠化中的应用效果  

Application Effect of Weiwei Prescription of Professor WU Yaonan's Experience Prescription in Patients with Chronic Atrophic Gastritis with Intestinal Metaplasia

作　　者：张冬英[1] 陈丽凤[2] 张玉凤[3] 张理[4] ZHANG Dongying;CHEN Lifeng;ZHANG Yufeng;ZHANG Li(Department of Gastroenterology,Xiamen Hospital of Traditional Chinese Medicine,Xiamen 361015,China;不详)

机构地区：[1]厦门市中医院消化内科,福建厦门361015 [2]厦门市中医院中医特色诊疗部,福建厦门361015 [3]厦门市中医院病理科,福建厦门361015 [4]厦门大学附属中山医院中医科,福建厦门361004

出　　处：《中国医学创新》2024年第23期122-125,共4页Medical Innovation of China

基　　金：第七批全国老中医药专家学术经验继承工作项目(国中医药人教函〔2022〕76号);吴耀南全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号);福建省卫生健康委员会-省卫生健康科技计划项目(2021TG026)。

摘　　要：目的:探究吴耀南教授经验方胃萎方在慢性萎缩性胃炎伴肠化中的疗效及对组织凋亡因子表达的影响。方法:选择2021年11月—2023年6月厦门市中医院收治的120例慢性萎缩性胃炎伴肠化患者作为研究对象。根据随机数字表法分为对照组和观察组,各60例。对照组给予常规治疗,观察组则采用吴耀南教授经验方胃萎方治疗。比较两组的临床总有效率、治疗前后的中医症候积分、病理评分、组织凋亡因子[B细胞淋巴瘤-2(Bcl-2)、环氧化酶-2(Cox-2)及脂肪酸合成酶(Fas)]。结果:观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组中医症候积分、病理评分、组织凋亡因子比较,差异均无统计学意义(P>0.05);治疗后,两组中医症候积分、病理评分、Bcl-2及Cox-2表达程度均显著低于治疗前,Fas表达程度均显著高于治疗前,且观察组中医症候积分、病理评分、Bcl-2及Cox-2表达程度均显著低于对照组,Fas表达程度显著高于对照组,差异均有统计学意义(P<0.05)。结论:吴耀南教授经验方胃萎方在慢性萎缩性胃炎伴肠化中的疗效甚佳,且可显著改善患者的组织凋亡因子的表达。Objective:To explore the effect of Weiwei Prescription of professor Wu Yaonan's experience prescription on chronic atrophic gastritis with intestinal metaplasia and its influence on the expression of apoptosis factors.Method:A total of 120 patients with chronic atrophic gastritis with intestinal metaplasia treated in Xiamen Hospital of Traditional Chinese Medicine from November 2021 to June 2023 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with of Weiwei Prescription of professor Wu Yaonan's experience prescription.The clinical total effective rate,traditional Chinese medicine symptom score,pathological score,tissue apoptosis factors[B-cell lymphomato-2(Bcl-2),cyclooxygenase-2(Cox-2)and fatty acid synthetase(Fas)]before and after treatment between the two groups were compared.Result:The total clinical effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in traditional Chinese medicine syndrome score,pathological score and tissue apoptosis factor between the two groups(P>0.05);after treatment,traditional Chinese medicine symptom scores,pathological scores,expression of Bcl-2 and Cox-2 in two groups were significantly lower than those before treatment,expression of Fas were significantly higher than those before treatment,and traditional Chinese medicine symptom score,pathological score,expression of Bcl-2 and Cox-2 in observation group were significantly lower than those in control group,expression of Fas was significantly higher than that in control group,the differences were statistically significant(P<0.05).Conclusion:Weiwei Prescription of professor Wu Yaonan's experience prescription has a good effect on chronic atrophic gastritis with intestinal metap

关 键 词：吴耀南教授经验方 胃萎方 慢性萎缩性胃炎 肠化 组织凋亡因子 

分 类 号：R259[医药卫生—中西医结合]