2020-2023年如皋地区艾滋病初治病例感染及免疫情况调查分析  

Investigation and Analysis of Infection and Immunity of Newly Treated Acquired Immune Deficiency Syndrome Patients in Rugao District from 2020 to 2023

作　　者：金鑫 高礼勇 JIN Xin;GAO Liyong(Microbiological Laboratory,Rugao Center for Disease Control and Prevention,Rugao 226500,China;不详)

机构地区：[1]如皋市疾病预防控制中心微生物检验科,江苏如皋226500 [2]如皋市疾病预防控制中心办公室,江苏如皋226500

出　　处：《中国医学创新》2024年第23期148-153,共6页Medical Innovation of China

摘　　要：目的:分析2020—2023年如皋市艾滋病(AIDS)初治病例的感染及免疫情况。方法:回顾性选择2020—2023年于如皋市疾病预防控制中心确诊的222例AIDS初治病例,对患者治疗前采集的血液进行检测,分析患者蛋白质印迹法(western blotting,WB)条带类型、CD4^(+)T淋巴细胞计数、人类免疫缺陷病毒(human immunodeficiency virus,HIV)、乙型肝炎病毒(hepatitis B virus,HBV)及丙型肝炎病毒(hepatitis C virus,HCV)载量、血清白蛋白、丙氨酸氨基转移酶(alanine transaminase,ALT)和天门冬氨酸氨基转移酶(aspartate transaminase,AST)检测结果。结果:222例AIDS初治患者中,男性、>50岁、初中文化程度、异性传播占比最高;其中有8例ALT高于正常范围,11例AST高于正常范围,未检出低于ALT与AST正常范围的病例。Pearson相关系数分析显示,CD4^(+)T淋巴细胞计数与病毒载量呈负相关(r=-0.627,P<0.05)。222例AIDS初治患者中,机会性并发感染者18例,其中HIV/HBV与HIV/HCV占比较高,分别为38.89%、44.44%,HIV/HBV/HCV占比最少,为16.67%。GP160、GP120、GP41平均检出率为98.95%;P66、P51、P31平均检出率为91.89%;P55、P39、P24、P17平均检出率为64.19%;P36与GP36平均检出率为1.58%。P39条带在<30岁患者中占比高于其他年龄,差异有统计学意义(P<0.05),其他带型在不同年龄及性别中分布比较,差异均无统计学意义(P>0.05)。结论:2020—2023年如皋市AIDS初治病例中男性、初中文化程度、>50岁及异性传播占比最高,WB带型特征检测HIV病毒可辅助判定不确定样本。Objective:To analyse the infection and immunity of acquired immune deficiency syndrome(AIDS)patients in Rugao City from 2020 to 2023.Method:A total of 222 newly treated AIDS patients diagnosed in the Rugao Center for Disease Control and Prevention from 2020 to 2023 were retrospectively selected.Blood collected from patients before treatment were tested,and western blotting(WB)band type,CD4^(+)T lymphocyte count,human immunodeficiency virus(HIV),hepatitis B virus(HBV)and hepatitis C virus(HCV)loads,serum albumin,alanine transaminase(ALT)and aspartate transaminase(AST)test result were analyzed.Result:Among 222 cases of AIDS patients,male,>50 years old,junior high school education,heterosexual transmission accounted for the highest proportion;there were 8 cases with ALT above the normal range,11 cases with AST above the normal range,and no cases below the normal range of ALT and AST were detected.Pearson correlation coefficient analysis showed that CD4^(+)T lymphocyte count was negatively correlated with viral load(r=-0.627,P<0.05).Among 222 AIDS patients,18 cases of opportunistic co-infection,of which HIV/HBV and HIV/HCV accounted for a relatively high proportion,38.89%and 44.44%,respectively,HIV/HBV/HCV accounted for the least proportion,16.67%.The average detection rate of GP160,GP120 and GP41 was 98.95%,the average detection rate of P66,P51 and P31 was 91.89%,the average detection rate of P55,P39,P24 and P17 was 64.19%,the average detection rate of P36 and GP36 was 1.58%.The proportion of P39 bands in patients<30 years old was higher than that in other ages,the difference was statistically significant(P<0.05),and there were no statistical significances in the distribution of other bands in different ages and genders(P>0.05).Conclusion:From 2020 to 2023,the proportion of male,junior high school education,>50 years old and heterosexual transmission are the highest among the initial AIDS patients in Rugao City.The detection of HIV virus with WB band type characteristics could assist in determining uncertain samples

关 键 词：艾滋病 初治 感染 免疫 蛋白质印迹法 

分 类 号：R512.91[医药卫生—内科学] R181.3[医药卫生—临床医学]