老年慢性心肾综合征与脂蛋白a及尿酸的关系分析  

Correlation analysis of chronic cardio-renal syndrome with lipoprotein a and uric acid in the elderly

作　　者：严新美 黎兰芳 YAN Xin-mei;LI Lan-fang(Department of Geriatric Medicine,Xinyu People's Hospital,Xinyu 338000,China)

机构地区：[1]江西省新余市人民医院老年医学科,338000

出　　处：《中国实用医药》2024年第16期56-59,共4页China Practical Medicine

基　　金：江西省卫生健康委科技项目(项目编号:202212235)项目名称:老年慢性心肾综合征与脂蛋白a及尿酸关系。

摘　　要：目的研究老年慢性心肾综合征与脂蛋白a及尿酸的关系。方法202例老年慢性心力衰竭患者,根据肾小球滤过率(eGFR)水平不同分为分为观察组[eGFR<90 ml/(min·1.73 m^(2)),慢性心肾综合征,126例]和对照组[eGFR≥90 ml/(min·1.73 m^(2)),慢性心力衰竭,76例]。观察组患者根据eGFR水平不同分为A组[60 ml/(min·1.73 m^(2))≤eGFR<90 ml/(min·1.73 m^(2)),51例]、B组[30 ml/(min·1.73 m^(2))≤eGFR<60 ml/(min·1.73 m^(2)),42例]、C组[15 ml/(min·1.73 m^(2))≤eGFR<30 ml/(min·1.73 m^(2)),33例]。①比较观察组和对照组患者临床资料;②比较观察组和对照组患者脂蛋白a水平、尿酸水平;③比较观察组不同eGFR患者脂蛋白a、尿酸水平;④比较观察组不同左室射血分数(LVEF)患者脂蛋白a、尿酸水平。结果观察组和对照组患者年龄、性别、高血压、糖尿病、高血脂、吸烟、冠心病、体质量指数(BMI)比较无显著统计学差异(P>0.05)。观察组患者脂蛋白a、尿酸水平分别为(268.11±30.54)mg/L、(442.91±95.38)μmol/L,均明显高于对照组的(109.01±20.27)mg/L、(186.72±55.21)μmol/L(P<0.05)。C组患者脂蛋白a、尿酸水平明显高于A组、B组,B组患者明显高于A组(P<0.05)。观察组LVEF≥45%患者脂蛋白a、尿酸水平低于LVEF<45%患者(P<0.05)。结论老年慢性心肾综合征患者脂蛋白a、尿酸水平明显高于慢性心力衰竭患者,同时慢性心肾综合征患者eGFR、LVEF越低,其尿酸水平、脂蛋白a水平越高。因此,临床医生可通过控制脂蛋白a及尿酸水平,提前干预,减少慢性心肾综合征的发生,从而降低住院率及死亡率,减少患者痛苦,减轻经济负担和社会负担。Objective To study the correlation of chronic cardio-renal syndrome with lipoprotein a and uric acid in the elderly.Methods A total of 202 elderly patients with chronic heart failure were selected.According to the level of estimated glomerular filtration rate(eGFR),they were divided into an observation group[eGFR<90 ml/(min·1.73 m^(2)),chronic cardio-renal syndrome,126 cases]and a control group[eGFR≥90 ml/(min·1.73 m^(2)),chronic heart failure,76 cases].According to the level of eGFR,patients in the observation group were divided into group A[60 ml/(min·1.73 m^(2))≤eGFR<90 ml/(min·1.73 m^(2)),51 cases],group B[30 ml/(min·1.73 m^(2))≤eGFR<60 ml/(min·1.73 m^(2)),42 cases]and group C[15 ml/(min·1.73 m^(2))≤eGFR<30 ml/(min·1.73 m^(2)),33 cases].(i)Comparison of clinical data between the observation group and the control group;(ii)Comparison of levels of lipoprotein a and uric acid between the observation group and the control group;(iii)Comparison of lipoprotein a and uric acid levels in patients with different eGFR in the observation group;(iv)Comparison of lipoprotein a and uric acid levels in patients with different LVEF in the observation group.Results There were no significant differences in age,sex,hypertension,diabetes,hyperlipidemia,smoking,coronary heart disease and body mass index(BMI)between the observation group and the control group(P>0.05).The levels of lipoprotein a and uric acid in the observation group were(268.11±30.54)mg/L and(442.91±95.38)μmol/L,which were significantly higher than(109.01±20.27)mg/L and(186.72±55.21)μmol/L in the control group(P<0.05).The levels of lipoprotein a and uric acid in group C were significantly higher than those in group A and group B,while the above indicators in group B were significantly higher than those in group A(P<0.05).The levels of lipoprotein a and uric acid in patients with LVEF≥45%were lower than those in patients with LVEF<45%(P<0.05).Conclusion The levels of lipoprotein a and uric acid in elderly patients with chronic cardio-renal s

关 键 词：老年 慢性心肾综合征 左室射血分数 尿酸 脂蛋白A 

分 类 号：R541.6[医药卫生—心血管疾病] R692.5[医药卫生—内科学]