黄葵胶囊联合常规西药治疗小儿PNS的临床效果  

Add to Favorite Clinical effects of Huangkui capsule combined with conventional western medicinein the treatment of children with PNS

作　　者：葛晓慧 张晓晓 GE Xiaohui;ZHANG Xiaoxiao(Department of Traditional Chinese Medicine,Jinshui District General Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市金水区总医院中医科,郑州450000

出　　处：《华夏医学》2024年第4期83-88,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关联合共建项目(LHGJ20219173)。

摘　　要：目的分析黄葵胶囊联合常规西药治疗小儿原发性肾病综合征(PNS)的临床效果。方法选取98例PNS患儿,按照随机数字表法分为常规西药组和中医联合组。常规西药组采用吗替麦考酚酯、醋酸泼尼松治疗,中医联合组采用中药黄葵胶囊联合吗替麦考酚酯、醋酸泼尼松治疗。治疗8周后,比较两组临床疗效、肾功能指标、血液流变学指标、炎性因子及不良反应发生率。结果治疗后,中医联合组临床总有效率为高于常规西药组,差异具有统计学意义(P<0.05);治疗后,中医联合组肾功能指标、血液流变学指标、炎性因子的水平均优于常规西药组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论黄葵胶囊联合醋酸泼尼松、吗替麦考酚酯治疗小儿PNS效果显著,可改善肾功能及炎症状态,降低血液流变学指标,有利于患儿病情转归,且具有较高的安全性。Objective To analyze the clinical effects of Huangkui capsule combined with conventional western medicine in the treatment of children with primary nephrotic syndrome(PNS).Methods All 98 children with PNS were divided into the conventional western medicine group and traditional Chinese medicine(TCM)combined group by random number table method.The conventional western medicine group were treated with mycophenolate morphenate and prednisone acetate,while the TCM combined group were treated with Huangkui capsule combined with mycophenolate morphenate and prednisone acetate.After 8 weeks of treatment,the clinical efficacy,renal function indexes,hemorheology indexes,inflammatory factors and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the TCM combined group was 93.88%,which was higher than that of the conventional western medicine group 77.55%,showing a statistically significant difference(P<0.05).After treatment,the clinical efficacy,renal function indexes,hemorheology indexes,inflammatory factors and the incidence of adverse reactions in the TCM combined group were lower than those in the conventional western medicine group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Huangkui capsule combined with prednisone acetate and mycophenol morpheate is effective in the treatment of children with PNS,which can improve renal function and inflammation,reduce hemorheology,and is beneficial to the prognosis of children with high drug safety.

关 键 词：原发性肾病综合征 黄葵胶囊 吗替麦考酚酯 醋酸泼尼松 

分 类 号：R692[医药卫生—泌尿科学]