小儿肺咳颗粒辅助治疗小儿支原体感染伴CVA的疗效及对炎症因子的影响  

Curative effect of Xiao'er feike granule adjuvant treatment in pediatric mycoplasma pneumonia complicated by cough variant asthma and its influences on inflammatory factors

作　　者：侯红丽 张汶娟 周汴生 余燕娟 Hou Hongli;Zhang Wenjuan;Zhou Biansheng;Yu Yanjuan(Kaifeng Children's Hospital,Kaifeng 475000,Henan,China)

机构地区：[1]开封市儿童医院,河南开封475000 [2]郑州儿童医院/河南省儿童医院/郑州大学附属儿童医院,河南郑州450000

出　　处：《临床心身疾病杂志》2024年第5期96-100,共5页Journal of Clinical Psychosomatic Diseases

基　　金：河南省医学科技攻关计划联合共建项目(编号LHGJ20190929)。

摘　　要：目的探讨小儿肺咳颗粒辅助治疗小儿支原体感染伴咳嗽变异性哮喘(CVA)的疗效及对患儿白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)、C反应蛋白(CRP)水平的影响。方法将92例小儿支原体感染伴CVA患儿按简单随机分组法分为观察组(46例)与对照组(46例)。对照组患儿予以常规西药(阿奇霉素+特布他林)治疗,观察组患儿在对照组基础上联合小儿肺咳颗粒治疗,持续治疗14 d。比较两组患儿临床疗效、不良反应发生率,治疗前后中医证候积分、哮喘控制测试(ACT)、莱斯特咳嗽问卷(LCQ)、心理弹性量表(CD-RISC)评分及炎症因子(IL-4、IFN-γ、CRP)水平。结果观察组患儿治疗总有效率较对照组明显升高(P<0.05)。与对照组相比,观察组患儿治疗后中医证候积分更低(P<0.01),ACT、LCQ及CD-RISC评分更高(P<0.01)。与对照组相比,治疗后观察组患儿IL-4、CRP水平更低(P<0.01),IFN-γ水平更高(P<0.01)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论小儿肺咳颗粒辅助治疗小儿肺炎支原体感染伴CVA疗效较好,可缓解临床症状,控制哮喘进展,减轻炎症反应,提高患儿心理韧性和生活质量。Objective To explore the curative effect of Xiao'er feike granule adjuvant treatment in pediatric mycoplasma pneumonia(PMP)complicated by cough variant asthma(CVA)and its influences on interleukin-4(IL)-4,interferon-γ(IFN-γ)and C-reactive protein(CRP)level.Methods Ninetytwo children with PMP complicated by CVA were divided into observation(n=46)and control group(n=46)according to simple random grouping.Controls received routine Western medicine(azithromycin+terbutaline),on the basis of controls observation group was plus Xiao'er feike granules,and the treatment lasted for 14 days.Such indexes were compared between two groups as clinical effects,the incidence of adverse raections,pre-and post-treat TCM syndrome,Asthma Control Test(ACT),Leicester Cough Questionnaire(LCQ),Connor-Davidson Resilience Scale(CD-RISC)scores as well as IL-4,IFN-γand CRP level.Results The total effective rate was significantly higher in observation than control group(P<0.05).The TCM syndromes scores were lower(P<0.01)and scores on ACT,LCQ and CD-RISC were higher(P<0.01)in observation than control group.After treatment IL-4and CRP level were lower(P<0.01)and IFN-γwas higher(P<0.01)in observation than control group.Intergroup difference in the incidence of adverse reactions wasn't statistically significant(P>0.05).Conclusion The curative effect of Xiao'er feike granules adjuvant treatment in PMP with CVA is good,can alleviate clinical symptoms,control the progress of asthma,reduce inflammatory response,and improve mental resilience and quality of life.

关 键 词：小儿肺咳颗粒 小儿支原体感染 咳嗽变异性哮喘 疗效 白细胞介素-4 干扰素-Γ C反应蛋白 

分 类 号：R563.1[医药卫生—呼吸系统] R272[医药卫生—内科学]