小儿热速清颗粒辅助治疗小儿支原体肺炎的效果及对免疫球蛋白、致炎因子的影响  

Effect of Xiaoer Resuqing Granules in Adjuvant Treatment of Mycoplasma Pneumonia in Children and the Impact on Immunoglobulins and Proinflammatory Factors

作　　者：黄木兰 HUANG Mulan(Department of Pediatrics,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China)

机构地区：[1]赣州市妇幼保健院儿科,江西赣州341000

出　　处：《中国医学创新》2024年第24期55-60,共6页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202212349)。

摘　　要：目的:研究小儿热速清颗粒辅助治疗小儿支原体肺炎的效果及对免疫球蛋白、致炎因子的影响。方法:选取2021年1月—2023年12月于赣州市妇幼保健院进行治疗的100例支原体肺炎患儿,通过信封随机法分为中医组与对照组,各50例。对照组给予常规治疗,中医组在对照组基础上给予小儿热速清颗粒辅助治疗。比较两组治疗前后临床症状评分、免疫指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]、炎症因子[C反应蛋白(CRP)、血沉(ESR)、白细胞介素-6(IL-6)]、血常规[白细胞(WBC)、淋巴细胞(LY)、中性粒细胞(NE)、红细胞(RBC)、血红蛋白(Hb)、血小板(PLT)]及临床有效率。结果:治疗后,两组咳嗽、发热、肺部啰音评分均低于治疗前,且中医组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组IgA、IgG、IgM均高于治疗前,CRP、ESR、IL-6均低于治疗前,且中医组IgA、IgG、IgM均高于对照组,CRP、ESR、IL-6均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组WBC水平均低于治疗前,且中医组低于对照组,差异均有统计学意义(P<0.05);治疗前后,两组LY、NE、RBC、Hb、PLT比较,差异均无统计学意义(P>0.05)。中医组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:小儿热速清颗粒辅助治疗小儿支原体肺炎效果突出,能有效减轻患儿炎症反应程度、提高免疫功能。Objective:To study the effect of Xiaoer Resuqing Granules in adjuvant treatment of mycoplasma pneumonia in children and its influence on immunoglobulin and inflammatory factors.Method:A total of 100 children with mycoplasma pneumonia treated in Ganzhou Maternal and Child Health Hospital from January 2021 to December 2023 were selected and divided into traditional Chinese medicine group and control group by envelope random method,with 50 cases in each group.The control group was given conventional treatment,and the traditional Chinese medicine group was given Xiaoer Resuqing Granules adjuvant treatment on the basis of the control group.The clinical symptom scores,immune indexes[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],inflammatory factors[C reactive protein(CRP),erythrocyte sedimentation rate(ESR),interleukin-6(IL-6)],blood routine[white blood cells(WBC),lymphocyte(LY),neutrality(NE),red blood cell(RBC),hemoglobin(Hb),platelet(PLT)]before and after treatment and clinical response rate between the two groups were compared.Result:After treatment,the scores of cough,fever and pulmonary rales in two groups were lower than those before treatment,and those in the traditional Chinese medicine group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,IgA,IgG and IgM in both groups were higher than those before treatment,CRP,ESR and IL-6 were lower than those before treatment,and IgA,IgG and IgM in traditional Chinese medicine group were higher than those in control group,CRP,ESR and IL-6 were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,WBC levels in both groups were lower than those before treatment,and that in the traditional Chinese medicine group was lower than that in the control group,the differences were statistically significant(P<0.05).Before and after treatment,there were no significant differences in LY,NE,RBC,Hb and PLT between the two groups(P>0.05).The total effe

关 键 词：小儿支原体肺炎 小儿热速清颗粒 免疫球蛋白 C反应蛋白 血常规 

分 类 号：R725.6[医药卫生—儿科]