复方α-酮酸片对2型糖尿病性肾病维持血液透析患者肾性骨营养不良及机体营养状态的影响  

Influence of Compoundα-ketoacid Tablets for Renal Osteodystrophy and Body Nutritional State of Patients with Maintenance Hemodialysis for Type 2 Diabetes Nephropathy

作　　者：宋群平 黄银波 刘龙友 汪洋畅 SONG Qunping;HUANG Yinbo;LIU Longyou;WANG Yangchang(General Internal Medicine Department,Dongguan Guangji Hospital,Dongguan 523000,China;不详)

机构地区：[1]东莞广济医院普通内科,广东东莞523000 [2]清远康华医院血透室,广东清远541100 [3]清远市清新区人民医院血透室,广东清远541100

出　　处：《中国医学创新》2024年第25期46-50,共5页Medical Innovation of China

基　　金：2022年东莞市社会发展科技项目(20221800901502)。

摘　　要：目的:探究复方α-酮酸片对2型糖尿病性肾病维持血液透析患者肾性骨营养不良及机体营养状态影响。方法:将2022年8月—2023年10月东莞广济医院的92例2型糖尿病性肾病维持血液透析患者根据随机数字表法分为两组,每组46例。对照组进行常规治疗,观察组则在对照组的基础上加用复方α-酮酸片。两组均治疗6个月。比较两组的不良反应发生率、治疗前后的钙磷代谢指标(血磷及钙磷乘积)、肾性骨营养不良指标[总Ⅰ型前胶原氨基端前肽(TPⅠNP)及β-骨胶原交联(β-CTx)]及机体营养状态[主观整体营养评估表(SGA)评分、血清白蛋白(ALB)、前白蛋白(PA)及血红蛋白(Hb)]。结果:两组的不良反应发生率比较,差异均无统计学意义(P>0.05)。治疗前,两组的钙磷代谢指标、肾性骨营养不良指标及机体营养状态指标比较,差异均无统计学意义(P>0.05);治疗3、6个月后,两组钙磷代谢指标及肾性骨营养不良指标均较治疗前显著降低,血清ALB、PA及Hb均显著升高,观察组的钙磷代谢指标及肾性骨营养不良指标均显著低于对照组,SGA评分构成比均显著优于对照组,血清ALB、PA及Hb均显著高于对照组,差异均有统计学意义(P<0.05)。结论:复方α-酮酸片在2型糖尿病性肾病维持血液透析患者中的应用效果较好,安全性值得肯定,且可显著改善患者的肾性骨营养不良及机体营养状态。Objective:To investigate the influence of Compoundα-ketoacid Tablets for renal osteodystrophy and body nutritional state of patients with maintenance hemodialysis for type 2 diabetes nephropathy.Method:A total of 92 patients with maintenance hemodialysis for type 2 diabetes nephropathy in Dongguan Guangji Hospital from August 2022 to October 2023 were divided into two groups according to the random number table method,with 46 cases in each group.The control group was treated with routine treatment,the observation group was treated with Compoundα-ketoacid Tablets on the basis of control group.Two groups were treated for six months.Then the incidence of adverse reaction,calcium and phosphorus metabolism indexes(blood phosphorus and calcium-phosphorus product),renal osteodystrophy indexes[total procollagen typeⅠamino-terminal propeptide(TPⅠNP)andβ-Crosslaps(β-CTx)]and body nutritional state[subjective global assessment(SGA)score,serum albumin(ALB),prealbumin(PA)and hemoglobin(Hb)]before and after the treatment of two groups were compared.Result:There was no statistically significant difference in the incidence of the adverse reaction of two groups(P>0.05).Before treatment,the calcium and phosphorus metabolism indexes,renal osteodystrophy indexes and body nutritional state of two groups were compared,the differences were not statistically significant(P>0.05);after 3 and 6 months of the treatment,the calcium and phosphorus metabolism indexes and renal osteodystrophy indexes of two groups were were significantly decreased compared to those before treatment,the serum ALB,PA and Hb were significantly increased,the calcium and phosphorus metabolism indexes and renal osteodystrophy indexes of observation group were significantly lower than those of control group,the compositions of SGA scores were significantly better than those of control group,the serum ALB,PA and Hb were significantly higher than those of control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Co

关 键 词：复方α- 酮酸片 2型糖尿病性肾病 维持血液透析 肾性骨营养不良 机体营养状态 

分 类 号：R692.9[医药卫生—泌尿科学] R587.2[医药卫生—外科学]