糖尿病与主动脉夹层发病的研究进展  

Research Progress of Diabetes Mellitus and Aortic Dissection

作　　者：邹明锐 董圣军[1] 刘宝辉[1] 王傲 韩曰信 王玉玖[1] ZOU Mingrui;DONG Shengjun;LIU Baohui;WANG Ao;HAN Yuexin;WANG Yujiu(Department of Cardiovascular Surgery,Binzhou Medical University Hospital,Binzhou 256603,China;不详)

机构地区：[1]滨州医学院附属医院心脏大血管外科,山东滨州256603

出　　处：《中国医学创新》2024年第25期184-188,共5页Medical Innovation of China

基　　金：山东省自然科学基金资助项目(ZR2020QH017)。

摘　　要：主动脉夹层是病情凶险、进展迅速、死亡率高的心血管疾病,但其具体的发病机制尚不明确。当前,主动脉夹层和糖尿病是国内外临床研究热点,糖尿病被认为是心血管疾病的危险因素之一,而笔者在诸多研究中发现,糖尿病与主动脉夹层发病呈负相关性,即糖尿病对主动脉夹层具有一定的保护作用,其中包括保护主动脉管壁结构、抑制炎症因子分泌、降低主动脉管壁应力等。为更好地了解糖尿病与主动脉夹层之间的相互作用机制,本文将目前关于糖尿病与主动脉夹层的临床研究及相关分子通路做一综述。Aortic dissection is a cardiovascular disease with dangerous condition,rapid progress and high mortality,but its specific pathogenesis is still unclear.At present,aortic dissection and diabetes mellitus are the focus of clinical research at home and abroad.Diabetes mellitus is considered to be one of the risk factors for cardiovascular diseases,and authors have found in many studies that there is a negative correlation between diabetes mellitus and the incidence of aortic dissection,that is,diabetes mellitus has a certain protective effect on aortic dissection,including protecting the structure of the aortic wall,inhibiting the secretion of inflammatory factors,and reducing the stress of the aortic wall.In order to better understand the interaction mechanism between diabetes mellitus and aortic dissection,this article reviews the current clinical studies and related molecular pathways on diabetes mellitus and aortic dissection.

关 键 词：糖尿病 主动脉夹层 作用机制 炎症分子学 生物力学 

分 类 号：R543.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]