观察盐酸替罗非班联合心血管介入手术治疗急性心肌梗死疾病的效果  

Observation on the effect of tirofiban hydrochloride combined with cardiovascular interventional surgery in the treatment of acute myocardial infarction

作　　者：杨尚玉 YANG Shang-yu(Department of Cardiology,Zaozhuang Municipal Hospital,Zaozhuang 277000,China)

机构地区：[1]枣庄市立医院心内科,277000

出　　处：《中国现代药物应用》2024年第16期11-14,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究对急性心肌梗死患者实施盐酸替罗非班联合心血管介入手术治疗的临床效果。方法选择50例急性心肌梗死患者,采用随机数字表法分为实验组与参照组,各25例。其中参照组采取心血管介入手术治疗,实验组采取盐酸替罗非班联合心血管介入手术治疗。对比两组患者的临床疗效、心功能指标、TIMI血流分级状况和不良事件发生情况。结果实验组和参照组患者的总有效率分别为100.00%、76.00%,其中实验组更高,统计学差异显著(P<0.05)。治疗前,实验组左心室射血分数(LVEF)和左心室舒张末期内径(LVEDD)分别为(50.93±5.31)%、(64.21±4.33)mm,参照组分别为(50.89±5.27)%、(64.17±4.64)mm;治疗后,实验组LVEF和LVEDD分别为(58.04±4.56)%、(51.83±3.52)mm,参照组分别为(52.94±4.73)%、(57.11±3.73)mm。相比于治疗前,实验组治疗后LVEF明显升高,且高于参照组,LVEDD明显降低,且低于参照组,统计学差异显著(P<0.05);相比于治疗前,参照组LVEDD治疗后明显降低,统计学差异显著(P<0.05)。实验组患者的TIMI血流分级状况优于参照组,统计学差异显著(P<0.05)。实验组治疗后的不良事件发生率4.00%明显低于参照组的32.00%,统计学差异显著(P<0.05)。结论盐酸替罗非班联合心血管介入手术治疗急性心肌梗死疾病具有较好的临床效果,有效地改善了患者的心功能及冠状动脉血流状况,减少了不良事件的发生。Objective To study the clinical effect of tirofiban hydrochloride combined with cardiovascular interventional surgery in the treatment of acute myocardial infarction.Methods 50 patients with acute myocardial infarction were selected,and were divided into an experimental group and a reference group by random number table method,each with 25 cases.The reference group was treated with cardiovascular interventional surgery,and the experimental group was treated with tirofiban hydrochloride combined with cardiovascular interventional surgery.The clinical efficacy,cardiac function indexes,TIMI blood flow grading and adverse events were compared between the two groups.Results The total effective rates of the experimental group and the reference group were 100.00%and 76.00%;the experimental group was higher than the reference group,and there was statistically significant difference(P<0.05).Before treatment,the left ventricular ejection fraction(LVEF)and left ventricular end diastolic diameter(LVEDD)of the experimental group were(50.93±5.31)%and(64.21±4.33)mm,respectively,while those of the control group were(50.89±5.27)%and(64.17±4.64)mm,respectively.After treatment,the LVEF and LVEDD of the experimental group were(58.04±4.56)%and(51.83±3.52)mm,respectively,while those of the control group were(52.94±4.73)%and(57.11±3.73)mm,respectively.Compared with before treatment,LVEF in the experimental group was significantly higher and higher than the reference group after treatment,and LVEDD was significantly lower and lower than the reference group.There was statistically significant difference(P<0.05).Compared with before treatment,LVEDD in the reference group was significantly lower after treatment,and there was statistically significant difference(P<0.05).The TIMI blood flow grading of the experimental group was better than that of the reference group,and there was statistically significant difference(P<0.05).After treatment,the incidence rate of adverse events in the experimental group was 4.00%,which was significant

关 键 词：盐酸替罗非班 心血管介入手术 急性心肌梗死 临床疗效 

分 类 号：R542.22[医药卫生—心血管疾病]