细菌感染患者外周血中性粒细胞CD64指数的检测价值分析  

Value analysis of peripheral blood neutrophil CD64 index in patients with bacterial infection

作　　者：彭杰梅 陈小艳 刘伟 PENG Jie-mei;CHEN Xiao-yan;LIU Wei(Yichun Second People's Hospital,Yichun 336000,China)

机构地区：[1]宜春市第二人民医院,336000

出　　处：《中国现代药物应用》2024年第16期82-85,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析外周血中性粒细胞CD64(nCD64)指数对细菌感染的诊断价值。方法将48例细菌感染患者纳入至细菌感染组,另将60例健康者纳入至健康对照组。采集两组研究对象的静脉血标本,检测nCD64指数及降钙素原(PCT)、白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平。比较细菌感染组与健康对照组以及细菌感染患者预后不良组与预后良好组nCD64指数及PCT、WBC、CRP、IL-6水平;绘制受试者工作特征曲线(ROC曲线),分析nCD64指数及PCT、WBC、CRP、IL-6对细菌感染的诊断效能。结果细菌感染组患者nCD64指数(4.57±0.47)及PCT(2.45±0.31)μg/L、WBC(9.25±1.44)×10^(9)/L、CRP(7.59±1.17)mg/L、IL-6(10.37±1.13)pg/ml均明显高于健康对照组的(1.77±0.23)、(0.35±0.09)μg/L、(7.30±1.41)×10^(9)/L、(6.56±1.25)mg/L、(5.25±1.06)pg/ml,差异有统计学意义(P<0.05)。细菌感染患者预后不良组nCD64指数(5.39±0.50)及PCT(2.77±0.38)μg/L、WBC(10.07±1.23)×10^(9)/L、CRP(8.45±1.04)mg/L、IL-6(11.48±1.06)pg/ml均明显高于预后良好组的(3.54±0.52)、(1.94±0.35)μg/L、(8.36±1.34)×10^(9)/L、(7.23±0.78)mg/L、(9.26±1.02)pg/ml,差异有统计学意义(P<0.05)。nCD64指数在细菌感染诊断中的敏感度最高,达68.75%,其次为PCT,达64.58%;PCT在细菌感染诊断中的特异度最高,达93.33%,其次为nCD64指数,达90.00%。结论外周血nCD64指数在细菌感染中的诊断敏感度较高,而且nCD64指数可随患者病情变化发生改变,有助于临床鉴别诊断细菌感染并进行预后评估。Objective To analyze the value of peripheral blood neutrophil CD64(nCD64)index in the diagnosis of bacterial infection.Methods 48 patients with bacterial infection were included in the bacterial infection group,and 60 healthy subjects were included in the healthy control group.Venous blood specimens were collected from the two groups,and nCD64 index and levels of procalcitonin(PCT),white blood cell count(WBC),C-reactive protein(CRP),and interleukin-6(IL-6)were measured.The nCD64 index and the levels of PCT,WBC,CRP,and IL-6 were compared between the bacterial infection group and the healthy control group,as well as between the poor prognosis group and the good prognosis group of patients with bacterial infections;the receiver operating characteristic(ROC)curves of the subjects were plotted to analyze the diagnostic efficiency of the nCD64 index and the levels of PCT,WBC,CRP,and IL-6 for bacterial infections.Results The bacterial infection group had nCD64 index of(4.57±0.47),PCT of(2.45±0.31)μg/L,WBC of(9.25±1.44)×10^(9)/L,CRP of(7.59±1.17)mg/L,and IL-6 of(10.37±1.13)pg/ml,which were significantly higher than(1.77±0.23),(0.35±0.09)μg/L,(7.30±1.41)×10^(9)/L,(6.56±1.25)mg/L,and(5.25±1.06)pg/ml in the healthy control group,and the difference was statistically significant(P<0.05).The poor prognosis group had nCD64 index of(5.39±0.50)and PCT of(2.77±0.38)μg/L,WBC of(10.07±1.23)×10^(9)/L,CRP of(8.45±1.04)mg/L,and IL-6 of(11.48±1.06)pg/ml,which were significantly higher than(3.54±0.52),(1.94±0.35)μg/L,(8.36±1.34)×10^(9)/L,(7.23±0.78)mg/L,and(9.26±1.02)pg/ml in the good prognosis group,and the difference was statistically significant(P<0.05).The nCD64 index had the highest sensitivity in the diagnosis of bacterial infections at 68.75%followed by PCT at 64.58%;PCT had the highest specificity in the diagnosis of bacterial infections at 93.33%followed by nCD64 index at 90.00%.Conclusion The diagnostic sensitivity of peripheral blood nCD64 index in bacterial infections is high,and the nCD64 index ca

关 键 词：细菌感染 外周血 中性粒细胞CD64指数 诊断价值 预后评估 

分 类 号：R446.1[医药卫生—诊断学]