红霉素联合阿奇霉素序贯疗法与单用阿奇霉素治疗小儿支原体肺炎的效果对比  

Comparison of effect of erythromycin combined with azithromycin sequential therapy and azithromycin alone in the treatment of mycoplasma pneumonia in children

作　　者：邓灵芝[1] DENG Ling-zhi(Tengzhou Central People's Hospital,Zaozhuang 277599,China)

机构地区：[1]滕州市中心人民医院,277599

出　　处：《中国现代药物应用》2024年第16期99-102,共4页Chinese Journal of Modern Drug Application

摘　　要：目的对比在小儿支原体肺炎患儿治疗中采用阿奇霉素单用及红霉素联合阿奇霉素序贯疗法治疗的效果。方法选取68例小儿支原体肺炎患儿,以随机数字表法分为对照组(34例,单用阿奇霉素治疗)与研究组(34例,红霉素联合阿奇霉素序贯疗法治疗)。对比两组治疗总有效率,临床症状缓解时间及住院时间,炎性因子水平,肺功能指标。结果研究组治疗总有效率(94.12%)较对照组(73.53%)高(χ2=5.314,P<0.05)。研究组发热缓解时间(1.52±0.43)d、肺部湿啰音缓解时间(4.26±0.39)d、咳嗽缓解时间(3.74±0.43)d、白细胞计数恢复正常时间(5.35±0.46)d及住院时间(6.07±0.61)d较对照组的(3.75±0.71)、(7.04±0.64)、(7.12±0.67)、(7.62±0.55)、(8.11±0.57)d短(t=15.665、21.629、24.756、18.460、14.248,P<0.05)。治疗前,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)无显著差异(P>0.05);治疗后,研究组IL-6(7.17±1.06)pg/ml、CRP(3.22±0.42)mg/L、PCT(0.29±0.08)ng/ml较对照组的(10.51±1.13)pg/ml、(5.51±0.75)mg/L、(0.56±0.12)ng/ml低(t=12.570、15.534、10.916,P<0.05)。治疗前,两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)无显著差异(P>0.05);治疗后,研究组FEV1(2.08±0.45)L、FVC(3.28±0.41)L、FEV1/FVC(75.34±4.02)%较对照组的(1.71±0.29)L、(2.53±0.32)L、(67.81±3.34)%高(t=4.030、8.408、8.401,P<0.05)。结论红霉素联合阿奇霉素序贯疗法对小儿支原体肺炎患儿进行治疗可提高疗效,消除机体炎症反应,改善肺功能,进而缩短患儿的恢复时间。Objective To compare the effect of erythromycin combined with azithromycin sequential therapy and azithromycin alone in the treatment of mycoplasma pneumonia in children.Methods A total of 68 children with mycoplasma pneumonia were randomly divided into a control group(34 cases,azithromycin alone)and a study group(34 cases,erythromycin combined with azithromycin sequential therapy)according to random numerical table.The total effective rate,remission time of clinical symptoms,length of hospital stay,level of inflammatory factors and pulmonary function index were compared between the two groups.Results The total effective rate of the study group(94.12%)was higher than that of the control group(73.53%)(χ2=5.314,P<0.05).In the study group,the remission time of fever was(1.52±0.43)d,the remission time of lung rale was(4.26±0.39)d,the remission time of cough was(3.74±0.43)d,the recovery time of white blood cell count was(5.35±0.46)d and the length of hospital stay was(6.07±0.61)d,which were shorter than(3.75±0.71),(7.04±0.64),(7.12±0.67),(7.62±0.55)and(8.11±0.57)d in the control group(t=15.665,21.629,24.756,18.460,14.248;P<0.05).Before treatment,the interleukin-6(IL-6),C-reactive protein(CRP)and procalcitonin(PCT)were not significantly different between the two groups(P>0.05).After treatment,the study group had IL-6 of(7.17±1.06)pg/ml,CRP of(3.22±0.42)mg/L,PCT of(0.29±0.08)ng/ml,which were lower than(10.51±1.13)pg/ml,(5.51±0.75)mg/L,(0.56±0.12)ng/ml in the control group(t=12.570,15.534,10.916;P<0.05).Before treatment,forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC were not significantly different between the two groups(P>0.05).After treatment,the study group had FEV1 of(2.08±0.45)L,FVC of(3.28±0.41)L,and FEV1/FVC of(75.34±4.02)%,which were higher than(1.71±0.29)L,(2.53±0.32)L,and(67.81±3.34)%in the control group(t=4.030,8.408,8.401;P<0.05).Conclusion Erythromycin combined with azithromycin sequential therapy in the treatment of children with mycoplasma pneumon

关 键 词：小儿支原体肺炎 阿奇霉素 红霉素 肺功能 炎性因子 

分 类 号：R725.6[医药卫生—儿科]