不同抗菌药物联用对ICU重症感染患者抗感染治疗及对其病原菌清除的效果分析  

Analysis of the effect of different antimicrobial drug combinations on the anti-infective treatment and pathogen clearance of ICU patients with severe infections

作　　者：蒋军飞 JIANG Jun-fei(Department of Pharmacy,Jinxian Hospital of Jiangxi Provincial People's Hospital,Nanchang 331700,China)

机构地区：[1]江西省人民医院进贤医院药剂科,331700

出　　处：《中国现代药物应用》2024年第16期110-113,共4页Chinese Journal of Modern Drug Application

摘　　要：目的对重症加强护理病房(ICU)重症感染患者经不同抗菌药物联用治疗的效果予以分析。方法60例ICU重症感染患者,根据治疗方式的不同分为单一组和联合组,每组30例。单一组为患者提供单一抗菌药物治疗,联合组对患者给予多种抗菌药物联合治疗。比较两组患者治疗效果、病原菌清除率、临床各时间指标(咳嗽恢复时间、药物起效时间、机械通气时间)、免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、实验室指标[动脉血氧分压(PO2)、白细胞计数(WBC)、动脉血二氧化碳分压(PCO_(2))]。结果联合组总有效率93.33%与病原菌清除率90.00%高于单一组的70.00%、63.33%,差异明显(P<0.05)。联合组患者咳嗽恢复时间(4.85±1.10)d、药物起效时间(14.11±0.14)d、机械通气时间(2.86±0.14)d均短于单一组的(6.69±1.05)、(18.52±0.36)、(4.36±0.22)d,差异明显(P<0.05)。两组患者治疗后的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于治疗前,联合组CD3^(+)(65.14±3.58)%、CD4^(+)(41.63±2.05)%、CD4^(+)/CD8^(+)(1.69±0.25)均高于单一组的(55.26±2.05)%、(34.78±3.05)%、(1.29±0.14),CD8^(+)(23.47±2.14)%低于单一组的(26.36±2.05)%,差异明显(P<0.05)。两组患者治疗后PO2较治疗前升高,WBC、PCO_(2)较治疗前降低,且联合组PO2(11.58±1.36)kPa高于单一组的(9.56±0.35)kPa,WBC(8.63±1.24)×10^(9)/L、PCO_(2)(5.63±0.20)kPa低于单一组的(11.47±1.63)×10^(9)/L、(6.58±0.14)kPa,差异明显(P<0.05)。结论以多种抗菌药物联合治疗的ICU重症感染患者,效果显著,能有效清除病原菌,缩短病情恢复时间,有利于改善患者免疫功能和实验室指标。Objective To analyze the effect of different antimicrobial drug combinations on intensive care unit(ICU)patients with severe infections.Methods 60 ICU patients with severe infections were divided into a single group and a combined group according to the treatment modality,each consisting of 30 patients.In the single group,patients were provided with a single antimicrobial drug treatment according to the results,while in the combined group,patients were treated with multiple antimicrobial drugs.Both groups were compared in terms of therapeutic effect,pathogen clearance rate,clinical time indexes(cough recovery time,drug onset time,mechanical ventilation time),immune function(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),laboratory indicators[arterial partial pressure of oxygen(PO2),white blood cell count(WBC),and arterial partial pressure of carbon dioxide(PCO_(2))].Results In the combined group,the total effective rate was 93.33%and the pathogen clearance rate was 90.00%,which were higher than 70.00%and 63.33%in the single group,and the difference was significant(P<0.05).In the combined group,the cough recovery time was(4.85±1.10)d,the drug onset time was(14.11±0.14)d and the mechanical ventilation time was(2.86±0.14)d,which were all shorter than(6.69±1.05),(18.52±0.36)and(4.36±0.22)d in the single group.The difference was significant(P<0.05).After treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in both groups were higher than those before treatment,and CD8^(+)was lower than that before treatment;the combined group had CD3^(+)of(65.14±3.58)%,CD4^(+)of(41.63±2.05)%and CD4^(+)/CD8^(+)of(1.69±0.25),which were higher than(55.26±2.05)%,(34.78±3.05)%and(1.29±0.14)in the single group;CD8^(+)of(23.47±2.14)%in the combined group was lower than(26.36±2.05)%in the single group;the difference was significant(P<0.05).After treatment,PO2 was higher and WBC and PCO_(2) were lower in both groups than those before treatment;PO2 of(11.58±1.36)kPa in the combined group was higher than(9.56±0.35)kPa in the single group;the combi

关 键 词：重症加强护理病房 重症感染 不同抗菌药物 病原菌 抗感染 

分 类 号：R459.7[医药卫生—急诊医学]