Zn^(2+)-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing  

作　　者：Zhengzhe Han Lili Deng Shiyan Chen Huaping Wang Yinjun Huang 

机构地区：[1]Department of Orthopedic Surgery,and Shanghai Institute of Microsurgery on Extremities,Shanghai Sixth People’s Hospital,600 Yishan Road,Shanghai 200233,P.R.China [2]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,P.R.China [3]Department of Trauma Center,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,201600,P.R.China

出　　处：《Burns & Trauma》2023年第1期1-14,共14页烧伤与创伤（英文）

基　　金：supported by the National Natural Science Foundation of China(52003048);China Postdoctoral Science Foundation(2021 T140110).

摘　　要：Background:Wound healing is a process that requires angiogenesis and antibacterial activities and it remains a challenge for both experimental and clinical research worldwide.Zn2+has been reported to be widely involved in angiogenesis and exerts antibacterial effects,making it suitable as a treatment to promote wound healing.Therefore Zn2+-loaded adhesive bacterial cellulose hydrogel was designed to observe its angiogenic and antibacterial abilities in the wound healing process.Methods:The characterization,tensile strength,swelling behaviors and antibacterial activity of bacterial cellulose/polydopamine/zeolitic imidazolate framework-8(BC/PDA/ZIF8)hydrogels were tested.Cell-Counting-Kit-8(CCK8),transwell,tube formation and real time qunantitative PCR(qRT-PCR)assays were performed to evaluate the cell compatibility of BC/PDA/ZIF8 hydrogels in vitro.A full-thickness defect wound model and histological assays were used to evaluate the BC/PDA/ZIF8 hydrogels in vivo.Results:The prepared BC/PDA/ZIF8 hydrogels exhibited suitable mechanical strength,excellent swelling properties,good tissue adhesion,efficient angiogenic and antibacterial effects and good performance as a physical barrier.In vivo experiments showed that the BC/PDA/ZIF8 hydrogels accelerated wound healing in a full-thickness defect wound model by stimulating angiogenesis.Conclusions:This study proved that BC/PDA/ZIF8 hydrogels possess great potential for promoting satisfactory wound healing in full-thickness wound defects through antibacterial effects and improved cell proliferation,tissue formation,remodeling and re-epithelialization.

关 键 词：HYDROGEL Mechanical properties BIOCOMPATIBILITY Angiogenic effects Wound healing 

分 类 号：TQ427.26[化学工程]