Efficacy and safety of extracorporeal membrane oxygenation for burn patients: a comprehensive systematic review and meta-analysis  

作　　者：Xue Heng Peng Cai Zhiqiang Yuan Yizhi Peng Gaoxing Luo Haisheng Li 

机构地区：[1]Institute of Burn Research,State Key Laboratory of Trauma,Burns and Combined Injury,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing,400038,China [2]Department of Intensive Care Medicine,PLA 80th Group Army Hospital,Wei Fang City,Shan Dong Province,261000,China

出　　处：《Burns & Trauma》2023年第1期91-104,共14页烧伤与创伤（英文）

基　　金：supported by grants from National Natural Science Foundation of China(82002036).

摘　　要：Background:Respiratory and circulatory dysfunction are common complications and the leading causes of death among burn patients,especially in severe burns and inhalation injury.Recently,extracorporeal membrane oxygenation(ECMO)has been increasingly applied in burn patients.However,current clinical evidence is weak and conflicting.This study aimed to comprehensively evaluate the efficacy and safety of ECMO in burn patients.Methods:A comprehensive search of PubMed,Web of Science and Embase from inception to 18 March 2022 was performed to identify clinical studies on ECMO in burn patients.The main outcome was in-hospital mortality.Secondary outcomes included successful weaning from ECMO and complications associated with ECMO.Meta-analysis,meta-regression and subgroup analyses were conducted to pool the clinical efficacy and identify influencing factors.Results:Fifteen retrospective studies with 318 patients were finally included,without any control groups.The commonest indication for ECMO was severe acute respiratory distress syndrome(42.1%).Veno-venous ECMO was the commonest mode(75.29%).Pooled in-hospital mortality was 49%[95%confidence interval(CI)41-58%]in the total population,55%in adults and 35%in pediatrics.Meta-regression and subgroup analysis found that mortality significantly increased with inhalation injury but decreased with ECMO duration.For studies with percentage inhalation injury≥50%,pooled mortality(55%,95%CI 40-70%)was higher than in studies with percentage inhalation injury<50%(32%,95%CI 18-46%).For studies with ECMO duration≥10 days,pooled mortality(31%,95%CI 20-43%)was lower than in studies with ECMO duration<10 days(61%,95%CI 46-76%).In minor and major burns,pooled mortality was lower than in severe burns.Pooled percentage of successful weaning from ECMO was 65%(95%CI 46-84%)and inversely correlated with burn area.The overall rate of ECMO-related complications was 67.46%,and infection(30.77%)and bleedings(23.08%)were the two most common complications.About 49.26%of patients required continu

关 键 词：Extracorporeal membrane oxygenation BURNS Acute respiratory distress syndrome Inhalation injury 

分 类 号：R644[医药卫生—外科学]