ERK signaling waves via body-wall muscles guide planarian whole-body regeneration across long distances  

作　　者：Chenglu Xiao Jing-Wei Xiong 

机构地区：[1]National Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,ChinaAgricultural University,Beijing 100193,China [2]College of Future Technology,Peking University,Beijing 100871,China [3]College of Basic Medical Sciences,The Second Affiliated Hospital,Nanchang University,Nanchang 330031,China

出　　处：《Cell Regeneration》2023年第1期35-38,共4页细胞再生（英文）

基　　金：supported by grants from the National Key R&D Program of China(2018YFA0800501 and 2019YFA0801602);the National Natural Science Foundation of China(32230032,31730061,and 81870198).

摘　　要：Whole-body regeneration is a multifaceted process that reinstates a body to its initial three-dimension size and struc-ture after resection injury.It is well-known that signaling waves such as calcium and extracellular signal-related kinase(ERK)signaling waves can efficiently transmit information between tissues or cells.However,the mecha-nisms responsible for coordinating wound responses over long distances are largely unexplored.A recent study has reported that the propagation of ERK signaling waves via longitudinal body-wall muscles play an essential role in wound response and whole-body regeneration in planarians,underscoring the significance of feedback inter-actions between spatially distinct tissues during whole-body regeneration over long distances.These findings not only address the central questions of regenerative biology but also have potential implications for regenerative medicine.

关 键 词：WOUND planar BODY 

分 类 号：R33[医药卫生—人体生理学]