Advanced cryopreservation engineering strategies:the critical step to utilize stem cell products  

作　　者：Xiaohu Wang Enyu Wang Gang Zhao 

机构地区：[1]Department of Electronic Engineering and Information Science,University of Science and Technology of China,Hefei 230027,China

出　　处：《Cell Regeneration》2023年第1期119-132,共14页细胞再生（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82172114);the Anhui Provincial Natural Science Foundation for Distinguished Young Scholars(No.2108085J37);the National Key Research and Development Program of China(2022YFC2703000).

摘　　要：With the rapid development of stem cell-related therapies and regenerative medicine,the clinical application of stem cell products is on the rise.However,ensuring the effectiveness of these products after storage and transportation remains a challenge in the transformation to clinical trials.Cryopreservation technology allows for the long-term storage of cells while ensuring viability,making it a top priority for stem cell preservation.The field of cryopreservationrelated engineering technologies is thriving,and this review provides an overview of the background and basic principles of cryopreservation.It then delves into the main bioengineering technologies and strategies used in cryopreservation,including photothermal and electromagnetic rewarming,microencapsulation,and synergetic ice inhibition.Finally,the current challenges and future prospects in the field of efficient cryopreservation of stem cells are summarized and discussed.

关 键 词：Stem cell cryopreservation Photothermal rewarming Electromagnetic rewarming MICROENCAPSULATION Synergetic ice inhibition 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]