The alkynyl-containing compounds from mushrooms and their biological activities  

作　　者：Ji-shuang Qi Yingce Duan Zhao-chen Li Jin-ming Gao Jianzhao Qi Chengwei Liu 

机构地区：[1]Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang,College of Life Science,Northeast Forestry University,Harbin 150040,China [2]Shaanxi Key Laboratory of Natural Products&Chemical Biology,College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China

出　　处：《Natural Products and Bioprospecting》2023年第1期138-158,共21页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China(No.32370069 and U22A20369);the Fundamental Research Funds for the Central Universities(2572023AW40);the Natural Science Foundation of Heilongjiang Province of China(No.LH2023C035);the Key R&D Projects in Shaanxi Province of China(No.2023-YBSF-164).

摘　　要：Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties.They are a crucial natural source of bioactive secondary metabolites,and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal uses.Despite their relatively low abundance,naturally occurring alkynyl compounds have attracted considerable attention due to their high reactivity.Bioactivity studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities,including antitumor,antibacterial,antifungal,insecticidal,phototoxic,HIV-inhibitory,and immunosuppressive properties.This review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities,focusing mainly on cytotoxicity and anticancer effects.This review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms.Moreover,it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.

关 键 词：MUSHROOM Alkynyl compounds Bioactivity Chemical structures 

分 类 号：O62[理学—有机化学]