The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines  

作　　者：Yin-Zhong Fan Chun Tian Shun-Yao Tong Qing Liu Fan Xu Bao-Bao Shi Hong-Lian Ai Ji-Kai Liu 

机构地区：[1]School of Pharmaceutical Sciences,South-Central MinZu University,Wuhan 430074,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期266-277,共12页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China(32000011,82204239);Hubei Provincial Natural Science Foundation of China(2022CFB462);the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2022-KF03);the Fundamental Research Funds for the Central Universities,South-Central MinZu University(CZY23024).

摘　　要：A series of terpenoids(1-17),comprising six new compounds designated bipolariterpenes A-F(1-6)and eleven rec-ognized compounds(7-17),were isolated from the wheat culture of the potato endophytic fungus Bipolaris eleusines.Their structures and stereochemistry were clarified by HRESIMS,NMR,DP4+probability analyses,and computations for electronic circular dichroism(ECD).All compounds are made up of six meroterpenoids,four sesterterpenes and seven sesquiterpenes.Among them,four sesterterpenes(4,5,10,11)were investigated for their antifungal,antibacterial and cytotoxic properties,and six meroterpenoids(1-3,7-9)were evaluated for their antifungal properties.The compounds 7,9,and 10 had substantial antifungal activity against Epidermophyton floccosum at a concentration of 100μM.No antibacterial and cytotoxic activities were observed.

关 键 词：Endophytic fungus Bipolaris eleusines TERPENOIDS Isolation and structure elucidation Antifungal activity 

分 类 号：O62[理学—有机化学]