Terpenes extracted from marine sponges with antioxidant activity:a systematic review  

作　　者：Cintia Cristina Santi Martignago Beatriz Soares-Silva Julia Risso Parisi Lais Caroline Souza e Silva Renata Neves Granito Alessandra Mussi Ribeiro Ana Cláudia Muniz Renno Lorena Ramos Freitas de Sousa Anna Caroline Campos Aguiar 

机构地区：[1]Departamento de Biociências,Universidade Federal de São Paulo(UNIFESP),Rua Silva Jardim 136,Edifício Central,Santos,SP 11015-020,Brazil [2]Institute of Chemistry,Federal University of Catalão(UFCAT),Av.Dr.Lamartine Pinto de Avelar,1120 Vila Chaud,Catalão,GO 75704-020,Brazil

出　　处：《Natural Products and Bioprospecting》2023年第1期516-527,共12页应用天然产物（英文）

基　　金：the FAPESP(Fundação de AmparoàPesquisa do Estado de São Paulo)A.C.M.R(2019/10228-5);A.C.C.A.(2019/19708-0).FAPEG(Fundação de AmparoàPesquisa do Estado de Goiás)L.R.F.S(202110267000075).

摘　　要：Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms.The sponge’s secondary metabolites demonstrated various bioactivities and potential pharmacological properties.This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro.The review was performed in accordance with PRISMA guidelines.The main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in vitro.Searching in three different databases,two hundred articles were selected.After screening abstracts,titles and evaluating for eligibility of manuscripts 14 articles were included.The most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl(DPPH)and measurement of intracellular reactive oxygen species(ROS).It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in vitro.Scientific evidence of the studies included in this review was accessed by the GRADE analysis.Terpenes play an important ecological role,moreover these molecules have a pharmaceutical and industrial application.

关 键 词：ANTIOXIDANT Marine drugs SPONGE Free radical 

分 类 号：R284[医药卫生—中药学]