New halimane and clerodane diterpenoids from Croton cnidophyllus  

作　　者：Xun Wei Jia-Luo Huang Hua-Hua Gao Fang-Yu Yuan Gui-Hua Tang Sheng Yin 

机构地区：[1]School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期537-545,共9页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China(No.82273804);the Science and Technology Program of Guangzhou,China(No.202201011613);the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.SML2021SP301);the Open Program of Shenzhen Bay Laboratory(No.SZBL2021080601007);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y093);the Guangdong Basic and Applied Basic Research Foundation,China(No.2021B1515140062).

摘　　要：Three new halimane furanoditerpenoids(1-3)and three new clerodane furanoditerpenoids(4-6),along with seven known terpenoids including four pimarane diterpenoids(7-10)and three norisoprenoids(11-13)were isolated from the 95%EtOH extracts of the plants of Croton cnidophyllus.The 2D structures including absolute configuration of new furanoditerpenoids(1-6)were elucidated by analysis of their HRMS and NMR data as well as comparison of experi-mental and calculated ECD curves.Bioassay revealed that two compounds(8 and 9)possessed certain inhibitory effects against NO production stimulated by LPS,with IC_(50) values of 19.00±1.76 and 21.61±1.11μM,respectively.

关 键 词：EUPHORBIACEAE Croton cnidophyllus Furanoditerpenoids Anti-inflammatory activity 

分 类 号：O62[理学—有机化学]