Structural characterizations andα-glucosidase inhibitory activities of four Lepidium meyenii polysaccharides with different molecular weights  

作　　者：Luan Wen Zhou-Wei Wu Li-Wu Lin Abdulbaset Al-Romaima Xing-Rong Peng Ming-Hua Qiu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,Yunnan,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期568-576,共9页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China(No.31872675);the Cooperation Project with DR PLANT Company(2023).

摘　　要：Four polysaccharides(MCPa,MCPb,MCPc,MCPd)were obtained from Lepidium meyenii Walp.Their structures were characterized by chemical and instrumental methods including total sugar,uronic acid and protein content determi-nation,UV,IR and NMR spectroscopy,as well as monosaccharide composition determination and methylation analy-ses.Four polysaccharides were a group of glucans with different molecular weights ranging from 3.12 to 14.4 kDa,and shared a similar backbone chain consisting of(1→4)-glucose linkages with branches attached to C-3 and C-6.Furthermore,bioactivity assay showed that MCPs had concentration-dependent inhibitory activity onα-glucosidase.MCPb(Mw=10.1 kDa)and MCPc(Mw=5.62 kDa)with moderate molecular weights exhibited higher inhibitory activ-ity compared with MCPa and MCPd.

关 键 词：Lepidium meyenii POLYSACCHARIDE Molecular weight Structural characterization α-Glucosidase inhibition 

分 类 号：R93[医药卫生—生药学]