Uncarialines A-E,new alkaloids from Uncaria rhynchophylla and their anticoagulant activity  

作　　者：Ke-Pu Huang Li-Li Xu Sheng Li Yin-Ling Wei Lian Yang Xiao-Jiang Hao Hong-Ping He Yu Zhang 

机构地区：[1]School of Chinese Materia Medica,Yunnan University of Chinese Medicine,Kunming 650500,People’s Republic of China [2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期598-606,共9页应用天然产物（英文）

基　　金：Yunnan Applied Basic Research Projects(No.202301AS070057);National Key R&D Program of China(No.2022YFF1100301);Yunnan Revitalization Talents Support Plan-Young Talent Project(to Y.Zhang).

摘　　要：Uncarialines A-E(1-5),five undescribed monoterpene indole alkaloids,together with five known analogues were obtained from the stems of Uncaria rhynchophylla.Alkaloids 1-3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system,while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation.Their structures were characterized by a comprehensive analysis of MS,NMR,and ECD.Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time(p<0.001).

关 键 词：Uncaria rhynchophylla Monoterpene indole alkaloids Uncarialines A-E Anticoagulant activity 

分 类 号：O62[理学—有机化学]