Four new lanostane triterpenoids featuring extendedπ-conjugated systems from the stems of Kadsura coccinea  

作　　者：Qi-Qi Zhang Kun Hu Han-Dong Sun Pema-Tenzin Puno 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,Yunnan,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期607-614,共8页应用天然产物（英文）

基　　金：Natural Science Foundation of Yunnan Province(202101AT070188).

摘　　要：Four new 14(13→12)-abeolanostane triterpenoids featuring extendedπ-conjugated systems,kadcoccitanes E-H(1-4),were obtained from the stems of Kadsura coccinea through using a HPLC−UV-guided approach.Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations.Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines(HL-60,A-549,SMMC-7721,MDA-MB-231,SW-480)but none of them exhibited activities at the concentration 40μM.

关 键 词：Kadsura coccinea Lanostane triterpenoids Extendedπ-conjugated systems Quantum chemical calculation 

分 类 号：O62[理学—有机化学]