Antifungal alkaloids from Mahonia fortunei against pathogens of postharvest fruit  

作　　者：Xiao-Na Wang Zhao-Jie Wang Yun Zhao Huan Wang Mei-Ling Xiang Yang-Yang Liu Li-Xing Zhao Xiao-Dong Luo 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education and Yunnan Province,Yunnan Characteristic Plant Extraction Laboratory,School of Chemical Science and Technology,Yunnan University,Kunming 650500,People’s Republic of China [2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences Kunming,Kunming 650201,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期627-638,共12页应用天然产物（英文）

基　　金：NSFC,32170405,Xiao-Dong Luo;the High-level Talent Promotion and Training Project of Kunming,2022SCP003,Xiao-Dong Luo;Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform,2022YKZY001,Xiao-Dong Luo;Scientific and Technological Innovation Team of Yunnan Province,202105AE160006,Xiao-Dong Luo.

摘　　要：Postharvest pathogens can affect a wide range of fresh fruit and vegetables,including grapes,resulting in significant profit loss.Isoquinoline alkaloids of Mahonia fortunei,a Chinese herbal medicine,have been used to treat infectious microbes,which might be effective against postharvest pathogens.The phytochemical and bioactive investigation of this plant led to the isolation of 18 alkaloids,of which 9 compounds inhibited the growth of Botrytis cinerea and 4 compounds against Penicillium italicum.The antifungal alkaloids could change the mycelium morphology,the total lipid content,and leak the cell contents of B.cinerea.Furthermore,the two most potent antifungal alkaloids,berber-ine(13)completely inhibited effect on gray mold of table grape at 512 mg L^(−1),while jatrorrhizine(18)exhibited an inhibition rate>90%on grape rot at the same concentration,with lower cytotoxicity and residue than chlorothalonil,which suggested that ingredients of M.fortunei might be a low-toxicity,low-residue,eco-friendly botanical fungicide against postharvest pathogens.

关 键 词：Mahonia fortunei Chemical constituents Botrytis cinerea Penicillium italicum Anti-postharvest pathogens 

分 类 号：O62[理学—有机化学]