Anti-inflammatory maistemonine-class alkaloids of Stemona japonica  

作　　者：Cheng-Yong Tan Bao-Bao Shi Mei-Fen Bao Xiang-Hai Cai 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]School of Pharmaceutical Sciences,South-Central MinZu University,Wuhan 430074,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期650-656,共7页应用天然产物（英文）

摘　　要：Three hitherto undescribed Stemona alkaloids,named stemajapines A-C(1-3),along with six known alkaloids(4-9),were isolated and identified from the roots of Stemona japonica(Blume)Miq.(Stemonaceae).Their structures were established by the analysis of the mass data,NMR spectra,and computational chemistry.Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine.Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids.Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC_(50) values of 19.7 and 13.8μM,respectively,compared to positive control dexamethasone with 11.7μM.The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.

关 键 词：Stemona japonica Stemona alkaloids Stemajapines A-C ANTI-INFLAMMATORY 

分 类 号：O62[理学—有机化学]