Alkaloids as potential antivirals.A comprehensive review  

作　　者：Shah Faisal Syed Lal Badshah Bibi Kubra Abdul-Hamid Emwas Mariusz Jaremko 

机构地区：[1]Department of Chemistry,Islamia College University Peshawar,Peshawar 25120,Pakistan [2]Core Labs,King Abdullah University of Science and Technology(KAUST),Thuwal 23955-6900,Saudi Arabia [3]Division of Biological and Environmental Sciences and Engineering(BESE),Smart-Health Initiative(SHI)and Red Sea Research Center(RSRC),King Abdullah University of Science and Technology(KAUST),Thuwal 23955-6900,Saudi Arabia

出　　处：《Natural Products and Bioprospecting》2023年第1期718-755,共38页应用天然产物（英文）

摘　　要：Alkaloids are a diverse group of natural phytochemicals.These phytochemicals in plants provide them protection against pests,and herbivorous organisms and also control their development.Numerous of these alkaloids have a variety of biological effects,and some have even been developed into medications with different medicinal properties.This review aims to provide a broad overview of the numerous naturally occurring alkaloids(isolated from both terrestrial and aquatic species)along with synthetically produced alkaloid compounds having prominent antiviral properties.Previous reviews on this subject have focused on the biological actions of both natural and synthetic alkaloids,but they have not gone into comprehensive detail about their antiviral properties.We reviewed here several antiviral alkaloids that have been described in the literature in different investigational environments i.e.(in-vivo,in-ovo,in-vitro,and in-silico),and found that these alkaloid compounds have significant antiviral properties against several infectious viruses.These alkaloids repressed and targeted various important stages of viral infection at non-toxic doses while some of the alkaloids reported here also exhibited comparable inhibitory activities to commercially used drugs.Overall,these anti-viral effects of alkaloids point to a high degree of specificity,implying that they could serve as effective and safe antiviral medicines if further pursued in medicinal and pharmacological investigations.

关 键 词：Alkaloid antivirals Antiviral agents Antiviral phytochemicals In vitro SPREAD Inhibition 

分 类 号：O62[理学—有机化学]