热毒宁联合抗生素对小儿支气管肺炎患儿NLR、PLR的影响  

Efficacy of reduning combined with antibiotics on NLR and PLR in children with bron⁃choppneumonia

作　　者：汪美琪 石韵 孙彦丽 WANG Meiqi;SHI Yun;SUN Yanli(Department of Pediatric Medicine,Wuhu Hospital of Traditional Chinese Medicine,Wuhu,Anhui,China,241000)

机构地区：[1]芜湖市中医医院小儿内科,安徽芜湖241000

出　　处：《分子诊断与治疗杂志》2024年第8期1429-1432,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省教育厅科研项目(KJ2021A286)。

摘　　要：目的探讨热毒宁联合抗生素对小儿支气管肺炎(BP)患儿中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)的影响。方法回顾性分析2021年4月至2022年2月芜湖市中医医院收治的84例BP患儿的资料,按治疗方法的不同分成抗生素组(42例,应用头孢硫脒治疗)和抗生素+热毒宁组(42例,在抗生素组基础上联合热毒宁治疗)。比较两组疗效、各临床表现消失情况、NLR、PLR、血清炎症指标[IL⁃6、降钙素原(PCT)]水平、药物不良反应(ADR)情况。结果抗生素+热毒宁组总有效率为95.24%,高于抗生素组的80.95%,差异有统计学意义(P<0.05);抗生素+热毒宁组咳嗽消失、体温恢复、肺啰音消失、肺部阴影消失时间均短于抗生素组,差异有统计学意义(P<0.05);治疗1周后,两组NLR、PLR及血清IL⁃6、PCT水平均低于治疗前,且抗生素+热毒宁组均低于抗生素组,差异有统计学意义(P<0.05);抗生素+热毒宁组ADR发生率9.52%和抗生素组的4.76%比较差异无统计学意义(P>0.05)。结论应用热毒宁联合抗生素治疗BP患儿的效果较好,可明显降低患儿NLR、PLR及血清炎症指标水平,有效促进症状消退。Objective To explore the efficacy of reduning combined with antibiotics on neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)in children with bronchopneumonia(BP).Methods A retrospective analysis was conducted on the data of 84 pediatric patients with BP who were admitted to our hospital from April 2021 to February 2022.According to different treatment methods,they were divided into an antibiotic group(42 cases,treated with cefoperazone)and an antibiotic+reduning group(42 cases,treated with reduning in addition to the antibiotic group).The efficacy,disappearance of clinical manifestations,NLR,PLR,serum inflammatory indicators[interleukin⁃6(IL⁃6),procalcitonin(PCT)]levels,and adverse drug reactions(ADRs)were compared between the two groups.Results The total effective rate was 95.24%in the antibiotic+reduning group,which was higher than the 80.95%in the antibiotic group,and the difference was statistically significant(P<0.05).The disappearance time of cough,body temperature,lung rales,and lung shadows in the antibiotic+reduning group was shorter than that in the antibiotic group,and the difference were statistically significant(P<0.05).After one week of treatment,the levels of NLR,PLR,serum IL⁃6,and PCT in both groups were lower than before treatment(P<0.05),with the antibiotic+reduning group were lower than the antibiotic group,and the difference were statistically significant(P<0.05).There was no difference in ADR between the antibiotic+reduning group(9.52%)and the antibiotic group(4.76%)(P>0.05).Conclusion The application of reduning combined with antibiotics for BP children has a positive effect.It can significantly reduce the levels of NLR,PLR,and serum inflammatory indicators,effectively promoting symptom resolution.

关 键 词：热毒宁 头孢硫脒 支气管肺炎 中性粒细胞 淋巴细胞 血小板 

分 类 号：R725.6[医药卫生—儿科]