冻干重组人脑利钠肽对缺血性心肌病心力衰竭患者NT⁃proBNP、AngⅡ、NE水平、心室重构和炎症因子的影响  

Effects of freeze⁃dried recombinant human brain natriuretic peptide on NT⁃proBNP,AngⅡ,NE levels,ventricular remodeling and inflammatory factors in ischemic cardiomyopa⁃thy and heart failure patients

作　　者：朱慧[1] 彭杰成[2] 马成亮[1] ZHU Hui;PENG Jiecheng;MA Chengliang(Department of Cardiovascular,Susong County People's Hospital,Susong,Anhui,China,246501;De-partment of Cardiovascular,Anqing First People's Hospital,Anqing,Anhui,China,246052)

机构地区：[1]宿松县人民医院心血管内科,安徽宿松246501 [2]安庆市第一人民医院心血管内科,安徽安庆246052

出　　处：《分子诊断与治疗杂志》2024年第8期1433-1436,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康委项目(AHWJ2021b103)。

摘　　要：目的探讨缺血性心肌病(ICM)心力衰竭(HF)患者应用冻干重组人脑利钠肽治疗对N末端脑钠肽前体(NT⁃proBNP)、血管紧张素Ⅱ(AngⅡ)、去甲肾上腺素(NE)水平、心室重构和炎症因子的影响。方法于2020年10月至2023年2月从宿松县人民医院选择86例ICM HF患者分为对照组和试验组,均43例,以随机数字表法分组。对照组和试验组分别予以常规治疗和冻干重组人脑利钠肽联合常规治疗,均治疗2周。比较两组疗效(治疗2周后)、血清NT⁃proBNP、AngⅡ、NE、心室重构指标和炎症因子水平(治疗前和治疗2周后)。结果治疗2周后,较对照组(74.42%),试验组总有效率(93.02%)更高,差异有统计学意义(χ^(2)=5.460,P<0.05)。两组治疗2周后的血清NT⁃proBNP、AngⅡ、NE、TNF⁃α、IL⁃6、IL⁃8和LVTWP、PWS、IVSS较治疗前降低,试验组更低,差异有统计学意义(t=5.672、20.016、55.416、6.742、5.851、5.258、5.940、6.681、5.865,P<0.05)。结论ICM HF患者应用冻干重组人脑利钠肽治疗可降低血清NT⁃proBNP、AngⅡ、NE水平,改善神经分泌功能,同时可抑制心室重构及机体炎症,疗效显著。Objective To investigate the effects of lyophilized recombinant human brain natriuretic peptide on levels of NT⁃proBNP,AngⅡ,NE,ventricular remodeling and inflammatory factors in ICM HF patients.Methods Eighty⁃six patients with ICM HF from our hospital were selected from October 2020 to February 2023.They were divided into a control and a trial groups,with 43 cases in each group using randomized numerical table method.The control group received conventional treatment,while the trial group was treated with lyophilized recombinant human brain natriuretic peptide in addition to conventional treatment for 2 weeks.After 2 weeks of treatment,the efficacy of both groups was evaluated.Serum levels of NT⁃proBNP,AngⅡ,NE,ventricular remodeling index,and inflammatory factors were compared before and after 2 weeks of treatment in both groups.Results After 2 weeks of treatment,the total effective rate(93.02%)was higher in the trial group compared to the control group(74.42%),and the difference was statistically significant(χ^(2)=5.460,P<0.05).Serum levels of NT⁃proBNP,AngⅡ,NE,TNF⁃α,IL⁃6,IL⁃8,LVTWP,PWS,and IVSS were lower in both groups after 2 weeks of treatment compared to before treatment.Additionally,these levels were lower in the trial group,with statistically significant differences(t=5.672,20.016,55.416,6.742,5.851,5.258,5.940,6.681,5.865,P<0.05).Conclusion Freeze⁃dried recombinant human brain natriuretic peptide could reduce NT⁃proBNP,AngⅡ,and NE in serum.It can also improve neurosecretory function,inhibit ventricular remodeling and inflammation in ICM HF patients,leading to a noticeable therapeutic effect.

关 键 词：缺血性心肌病 心力衰竭 重组人脑利钠肽 N末端脑钠肽前体 血管紧张素Ⅱ 去甲肾上腺素 心室重构 

分 类 号：R542.2[医药卫生—心血管疾病] R541.6[医药卫生—内科学]