北京某三甲医院健康体检女性HPV感染情况及TCT结果分析  

Analysis of HPV infection and TCT results in women with health examination in a tertiary hospital in Beijing

作　　者：朱浩妍 王道靖 姜永玮[1] 李沫 赵美美 孔晓牧[1] 刘怡 高芃 曹永彤[1] 马亮[1] ZHU Haoyan;WANG Daojing;JIANG Yongwei;LI Mo;ZHAO Meimei;KONG Xiaomu;LIU Yi;GAO Peng;CAO Yongtong;MA Liang(Clinical Laboratory of China-Japan Friendship Hospital,Beijing,China,100029;Clinical Laboratory of Ulanqab Maternal and Child Health Hospital,Ulanqab,Ulanqab Inner Mongolia,China,012000)

机构地区：[1]中日友好医院检验科,北京100029 [2]乌兰察布市妇幼保健院检验科,内蒙古乌兰察布012000

出　　处：《分子诊断与治疗杂志》2024年第8期1488-1492,共5页Journal of Molecular Diagnostics and Therapy

基　　金：中日友好医院“菁英计划”人才培育工程资助(NO.ZRJY2024⁃BJ02)。

摘　　要：目的探讨北京某三甲医院健康体检女性HPV感染情况及TCT结果分析,为本地区宫颈癌防治提供参考。方法回顾分析2022年7月至2023年9月于中日友好医院进行健康体检的10124例女性HPV及TCT结果。结果健康体检女性10124例中,HPV阳性率为7.34%,不同年龄段间HPV阳性率比较差异具有统计学意义(χ^(2)=29.721,P<0.001)。高危型HPV占比前五位亚型是HPV⁃52、HPV⁃58、HPV⁃51、HPV⁃16和HPV⁃39。TCT结果阳性率为2.49%,≥61岁人群ASC和HSIL占比最高,21~岁人群LSIL组占比最高。随着宫颈病变加重,从ASC到LSIL再到HSIL,HPV的阳性率逐渐升高(51.41%,70.18%,88.89%),不同程度宫颈病变的HPV阳性率比较差异具有统计学意义(χ^(2)=485.453,P<0.001),不同程度宫颈病变之间HPV感染类型比较差异有统计学意义(χ^(2)=18.943,P<0.001)。结论宫颈病变程度加重,HPV感染率升高,应重视本地区适龄妇女宫颈癌筛查。Objective To explore the HPV infection situation and TCT results analysis in female health examinations at a tertiary hospital in Beijing,so as to provide a reference for the prevention and treatment of cervical cancer in the region.Methods The results of HPV and TCT tests in 10124 women who underwent health check⁃ups at China⁃Japan Friendship Hospital from July 2022 to September 2023 were retrospectively analyzed.Results Among the 10124 women who underwent physical examination,the HPV positivity rate was 7.34%.The difference in HPV positivity rate among different age groups was statistically significant(χ^(2)=29.721,P<0.001).The top five high⁃risk HPV subtypes are HPV⁃52,HPV⁃58,HPV⁃51,HPV⁃16,and HPV⁃39.The positive rate of TCT results was 2.49%,≥61⁃year⁃old individuals had the highest proportion of ASC and HSIL,while those aged 21⁃31 had the highest proportion of LSIL.As cervical lesions worsen from ASC to LSIL to HSIL,the positive rate of HPV gradually increases(51.41%,70.18%,and 88.89%).The difference in HPV positive rate between different degrees of cervical lesions is statistically significant(χ^(2)=485.453,P<0.001),as well as the difference in the types of HPV infection between different degrees of cervical lesions(χ^(2)=18.943,P<0.001).Conclusion The severity of cervical lesions is worsening,and the rate of HPV infection is increasing.Therefore,it is crucial to emphasize cervical cancer screening among women of appropriate age in this region.

关 键 词：高危型人乳头瘤病毒 HPV亚型 TCT检测 健康体检人群 

分 类 号：R711.32[医药卫生—妇产科学]