冠心病患者sLOX⁃1、SREBP⁃1及sST2变化及与冠脉病变程度的关系  

Changes of sLOX⁃1,sST2 and SREBP⁃1 in patients with coronary heart disease and their relationship with the severity of coronary lesions

作　　者：云冬晔 孙欢 李静 王鹏 YUN Dongye;SUN Huan;LI Jing;WANG Peng(Department of Cardiovascular Medicine,Inner Mongolia Autonomous Region People's Hospital,Hohhot Inner Mongolia,China,010017;Department of Emergency,Inner Mongolia Autonomous Region People's Hospital,Hohhot Inner Mongolia,China,010017)

机构地区：[1]内蒙古自治区人民医院急诊心血管内科,内蒙古呼和浩特010017 [2]内蒙古自治区人民医院急诊科,内蒙古呼和浩特010017

出　　处：《分子诊断与治疗杂志》2024年第8期1515-1519,共5页Journal of Molecular Diagnostics and Therapy

基　　金：内蒙古自治区自然科学基金(2023WZ12)。

摘　　要：目的探究冠心病(CHD)患者血清可溶性凝集素样氧化低密度脂蛋白受体⁃1(sLOX⁃1)、可溶性生长刺激表达基因2蛋白(sST2)、固醇调节元件结合蛋白⁃1(SREBP⁃1)变化及与冠脉病变程度的关系。方法选择2020年4月至2022年4月于内蒙古自治区人民医院就诊的CHD患者156例作为CHD组,其中,稳定心绞痛(SAP)组51例,不稳定心绞痛(UAP)组63例,急性心肌梗死(AMI)组42例,选择同期来本院体检的健康人50名作为健康组。检测所有受试者的sLOX⁃1、sST2、SREBP⁃1表达水平及QRS波时限水平,比较健康者与CHD患者sLOX⁃1、sST2、SREBP⁃1及QRS波时限水平,比较不同Gensini积分患者中sLOX⁃1、sST2、SREBP⁃1及QRS波时限水平,比较不同冠心病病变支数患者中,sLOX⁃1、sST2、SREBP⁃1及QRS波时限水平,采用Spesrman相关系数分析CHD患者的sLOX⁃1、sST2,SREBP⁃1与冠脉病变程度及QRS波时限的关系。结果SAP组、UAP组、AMI组及健康组sLOX⁃1、sST2、SREBP⁃1、QRS波时限比较:AMI组>UAP组>SAP组>健康组,差异均有统计学意义(P<0.05)。0~20分组、20~40分组和≥40分组sLOX⁃1、sST2、SREBP⁃1和QRS波时限水平比较:≥40分组>20~40分组>0~20分组,差异均有统计学意义(P<0.05);冠脉病变三支组、双支组及单支组sLOX⁃1、sST2、SREBP⁃1及QRS波时限水平比较:三支组>双支组>单支组,差异均有统计学意义(P<0.05)。CHD组患者sLOX⁃1、sST2及SREBP⁃1水平与患者Gensini积分、冠脉病变支数、QRS波时限水平均呈正相关(P<0.05)。结论CHD患者sLOX⁃1、SREBP⁃1、sST2水平均高于健康人群,且与患者的冠脉病变严重程度相关,可作为临床防治CHD的靶点。Objective To explore the changes of serum soluble lectin⁃like oxidised low⁃density li⁃poprotein receptor⁃1(sLOX⁃1),sterol regulatory element binding protein⁃1(SREBP⁃1)and soluble growth stimulation expressed gene 2(sST2)in patients with coronary heart disease(CHD)and their relationship with the severity of coronary lesions.Methods A total of 156 patients with CHD treated at Inner Mongolia Autono⁃mous Region People's Hospital were enrolled in the CHD group between April 2020 and April 2022.This group included 51 cases of stable angina pectoris(SAP)group,63 cases of unstable angina pectoris(UAP)and 42 cases of acute myocardial infarction(AMI).Additionally,50 healthy controls were enrolled during the same pe⁃riod as the healthy group.The levels of sLOX⁃1,sST2 and SREBP⁃1,and QRS wave duration were detected in all subjects.These indexes were compared between healthy controls and CHD patients,and among patients with different Gensini scores and number of lesions were compared.The relationship between sLOX⁃1,sST2,SREBP⁃1,the severity of coronary lesions,and QRS wave duration was analyzed using the Spearman correlation coeffi⁃cient.Results There were significant differences in sLOX⁃1,sST2,SREBP⁃1 levels and QRS wave duration among the SAP group,UAP group,AMI group and healthy group(P<0.05).The levels of sLOX⁃1,sST2 and SREBP⁃1 and QRS wave duration were gradually decreased in AMI group,UAP group,SAP group and healthy group,and the differences were statistically significant(P<0.05).There were significant differences in sLOX⁃1,sST2,SREBP⁃1 levels and QRS wave duration among 0⁃20 point group,20⁃40 point group and≥40 point group(P<0.05).The levels of sLOX⁃1,sST2 and SREBP⁃1 and QRS wave duration were gradually decreased in≥40 point group,20⁃40 point group and 0⁃20 point group,and the differences were statistically significant(P<0.05).There were significant differences in sLOX⁃1,sST2,SREBP⁃1 levels and QRS wave duration among triple⁃ves⁃sel group,double⁃vessel

关 键 词：冠心病 血清可溶性凝集素样氧化低密度脂蛋白受体⁃1 固醇调节元件结合蛋白⁃1 可溶性生长刺激表达基因2蛋白 冠脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]