绝经后骨质疏松症患者“血瘀”水平与BGP、TRACP5b的相关性研究  

Study on the Correlation Between"Blood Stasis"Level and BGP,TRACP5b in Postmenopausal Osteoporosis Patients

作　　者：甘卫冬[1] 叶海程 樊孝俊[1] 陈舒强[1] 苏春涛[1] 陈祺[1] GAN Weidong;YE Haicheng;FAN Xiaojun;CHEN Shuqiang;SU Chuntao;CHEN Qi(Department of Rehabilitation Medicine,the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen Fujian 361003,China)

机构地区：[1]厦门大学附属第一医院康复医学科,福建厦门361003

出　　处：《中国卫生标准管理》2024年第16期31-34,共4页China Health Standard Management

基　　金：厦门市医疗卫生指导性项目(3502Z20199013)。

摘　　要：目的研究绝经后骨质疏松症女性“血瘀”水平前列环素(prostacyclin,PGI2)、血栓素A2(thromboxane A2,TXA2)与骨代谢指标骨钙素(bone glaprotein,BGP)、抗酒石酸酸性磷酸酶5b(tartrate-resistant acid phosphatase 5b,TRACP5b)之间相关性。方法选取2022年1—12月就诊于厦门大学附属第一医院的176例患者为研究对象。其中88例绝经后继发骨质疏松症的患者作为骨质疏松症组,88名无骨质疏松症临床表现的绝经后正常妇女作为正常对照组。分别检测2组血清PGI2、TXA2、BGP、TRACP5b等相关指标,再分析它们之间的相关性。结果骨质疏松症组TXA2为(139.34±6.56)ng/L,高于正常对照组的(112.61±6.91)ng/L,PGI2为(94.27±8.15)ng/L,低于正常对照组的(153.73±8.77)ng/L(P<0.05);骨质疏松症组BGP低于正常对照组,TRACP5b高于正常对照组(P<0.05);BGP与PGI2呈正相关,而与TXA2呈负相关;TRACP5b与TXA2呈正相关,而与PGI2呈负相关。结论骨质疏松症患者成骨活性分子BGP水平下降、破骨活性分子TRACP5b水平升高与血管活性因子PGI2水平降低、TXA2水平升高密切相关,舒张血管因子水平下降、收缩血管因子水平上调导致局部“血瘀”引起的局部骨代谢微循环病理改变与骨质疏松症的发病存在一定的相关性。Objective To study the correlation between"blood stasis"levels[prostacyclin(PGI2),thromboxane A2(TXA2)],and bone metabolism indexes[bone glaprotein(BGP)and tartrateresistant acid phosphatase 5b(TRACP5b)]in postmenopausal women with osteoporosis.Methods A total of 176 patients admitted to the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University from January to December 2022 were selected as the study objects.Among them,a total of 88 postmenopausal patients with secondary osteoporosis were used as the osteoporosis group,and 88 postmenopausal normal women without clinical manifestations of osteoporosis were used as the normal control group.Serum PGI2,TXA2,BGP,TRACP5b and other related indicators were detected in the 2 groups,and then the correlation between them was analyzed.Results TXA2 in osteoporosis group was(139.34±6.56)ng/L,higher than(112.61±6.91)ng/L in normal control group,PGI2 was(94.27±8.15)ng/L,lower than(153.73±8.77)ng/L in normal control group(P<0.05).BGP in osteoporosis group was lower than that in normal control group,TRACP5b was higher than that in normal control group(P<0.05).BGP was positively correlated with PGI2,but negatively correlated with TXA2.TRACP5b was positively correlated with TXA2,but negatively correlated with PGI2.Conclusion In patients with osteoporosis,the decreased level of osteogenic active molecule BGP and the increased level of osteoclastogenic active molecule TRACP5b are closely related to the decreased level of vasoactive factor PGI2 and increased level of TXA2.The pathological changes of local bone metabolism microcirculation caused by"blood stasis"caused by the decrease of vasodilator factor level and the increase of vasodilator factor level are related to the incidence of osteoporosis.

关 键 词：骨质疏松症 血瘀 PGI2 TXA2 BGP TRACP5B 

分 类 号：R580[医药卫生—内分泌]