复方托吡卡胺不同给药方法对儿童瞳孔散大效果影响的临床研究  

Pupil-dilating effects of different administration methods of topicarbamide in children:a preliminary clinical study

作　　者：续旭 张连新[1] 蒋晶晶[1] 张诚玥[1] Xu Xu;Zhang Lianxin;Jiang Jingjing;Zhang Chengyue(Department of Ophthalmology,Beijing Children’s Hospital,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院,北京100045

出　　处：《中华临床医师杂志（电子版）》2024年第1期7-10,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：首都医科大学附属北京儿童医院院级护理课题(YHL202205)。

摘　　要：目的研究复方托吡卡胺滴眼液不同给药方法对儿童瞳孔散大效果的影响。方法本研究为前瞻性随机对照研究。收集2022年5月~2022年12月在北京儿童医院眼科住院行全麻眼底检查的患儿共88人(168只眼)。随机分为试验组和对照组。对照组(按照药物使用说明)采用复方托吡卡胺滴眼液术前点眼,每3 min一次,共3次;试验组采用复方托吡卡胺滴眼液点眼,每5 min一次,共4次。分别测量散瞳前、点药结束后0 min及20 min的瞳孔直径大小。结果对照组与试验组患儿在年龄和性别上差异无统计学意义(P>0.05)。对照组散瞳前、滴药后0 min、20 min瞳孔直径分别为(3.88±0.52)mm、(4.81±0.77)mm和(6.12±0.90)mm。试验组散瞳前、滴药后0 min、20 min瞳孔直径分别为(3.78±0.38)mm、(6.14±1.00)mm、(7.58±1.01)mm。2组患者在滴药后0 min及20 min瞳孔直径大小存在显著统计学差异(P<0.05)。结论针对儿童应用复方托吡卡胺滴眼液散瞳,采用每5 min点一次,共4次的方法,散瞳效果更佳。Objective To investigate the pupil-dilating effects of different administration methods of compound topicarbamide eye drops in children.Methods This is a prospective randomized controlled study in which 88 patients(168 eyes)who received fundus examination under general anesthesia at the Department of Ophthalmology of Beijing Children's Hospital from May 2022 to December 2022 were included.These patients were divided randomly into either an experimental group or a control group.Compound topiramide was used for three times every three minutes before surgery in the control group.Compound topiramide was administered for four times every five minutes in the experimental group.The pupil diameters were measured before application of eye drop as well as 0 minute and 20 minutes after application.Results There was no significant differences in age or gender between the control group and the experimental group(P>0.05).The pupil diameters before application and 0 minute and 20 minutes after application in the control group were(3.88±0.52)mm,(4.81±0.77)mm,and(6.12±0.90)mm,respectively;the corresponding values in the experimental group were(3.78±0.38)mm,(6.14±1.00)mm,and(7.58±1.01)mm.There was a statistically significant difference in pupil diameter between the two groups at 0 min and 20 min after usage(P<0.05).Conclusion The new administration method of compound topicarbamide(four times once every five minutes)can achieve better effect on pupil size for children who need fundus examination.

关 键 词：儿童 瞳孔 眼底检查 

分 类 号：R72[医药卫生—儿科]