门冬胰岛素治疗妊娠糖尿病基础上加用地特胰岛素对糖脂代谢的影响  

Effect of Insulin Aspart Combined with Insulin Detemir on Glucose and Lipid Metabolism in the Treatment of Gestational Diabetes Mellitus

作　　者：陈丽萍 黄秋香 郑雅芳 CHEN Liping;HUANG Qiuxiang;ZHENG Yafang(Department of Obstetrics and Gynecology,Yongchun County Hospital,Quanzhou 362601,Fujian,China;Department of Obstetrics and Gynecology,Quanzhou First Hospital,Quanzhou 362000,Fujian,China)

机构地区：[1]泉州市永春县医院妇产科,福建泉州362601 [2]泉州市第一医院妇产科,福建泉州362000

出　　处：《糖尿病新世界》2024年第12期112-115,共4页Diabetes New World

摘　　要：目的探究地特胰岛素联用门冬胰岛素治疗妊娠期糖尿病(gestational diabetes mellitus,GDM)的效果及对糖脂代谢的影响。方法回顾性选取2023年1月—2024年3月于泉州市永春县医院就诊的120例GDM患者的临床资料,根据不同治疗手段分为参照组(以门冬胰岛素治疗)、观察组(以门冬胰岛素加用地特胰岛素治疗),各60例。比较两组糖脂代谢水平(餐后2 h血糖、空腹血糖、总胆固醇、甘油三酯)、胰岛功能(胰岛素分泌指数、胰岛素抵抗指数)。结果治疗后,观察组糖脂代谢水平低于参照组,差异有统计学意义(P均<0.05)。治疗后,观察组胰岛素分泌指数高于参照组,胰岛素抵抗指数低于参照组,差异有统计学意义(P均<0.05)。结论GDM治疗中基于门冬胰岛素加入地特胰岛素,可改善糖脂代谢水平及胰岛素抵抗。Objective To explore the effect of insulin detemir combined with insulin aspart in the treatment of gesta-tional diabetes mellitus(GDM)and the effect on glucose and lipid metabolism.Methods The clinical data of 120 pa-tients with GDM who were treated in Yongchun County Hospital from January 2023 to March 2024 were retrospec-tively selected.According to different treatment methods,they were divided into reference group(insulin aspart treat-ment)and observation group(insulin aspart plus insulin detemir treatment),with 60 cases in each group.The levels of glucose and lipid metabolism(2-hour postprandial blood glucose,fasting blood glucose,total cholesterol,triglyceride)and islet function(insulin secretion index,insulin resistance index)were compared between the two groups.Results After treatment,the glucose and lipid metabolism levels of the observation group were lower than those of the reference group,and the differences were statistically significant(all P<0.05).After treatment,the insulin secretion index of the observation group was higher than that of the reference group,and the insulion resistance index was lower than that of the reference group,the differences were statistically significant(both P<0.05).Conclusion The addition of in-sulin detemir based on insulin aspart in the treatment of GDM can improve the level of glucose and lipid metabolism and insulin resistance.

关 键 词：妊娠期糖尿病 门冬胰岛素 地特胰岛素 糖脂代谢 胰岛素抵抗 

分 类 号：R71[医药卫生—妇产科学]