压电生物传感器及其在医疗健康中的应用  

Piezoelectric Biosensor and Its Application in Healthcare

作　　者：钟兴平 陈艳霞 陈晨[1] 秦雷[1] 张学记 Xingping Zhong;Yanxia Chen;Chen Chen;Lei Qin;Xueji Zhang(Beijing Key Laboratory of Sensors,Beijing Information Science&Technology University,Beijing 100101,China;School of Medicine,Tsinghua University,Beijing 100084,China;School of Biomedical Engineering,Shenzhen University,Shenzhen 518060,China)

机构地区：[1]北京信息科技大学北京市传感器重点实验室,北京100101 [2]清华大学医学院,北京100084 [3]深圳大学生物医学工程学院,深圳518060

出　　处：《化学进展》2024年第7期975-986,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.22004009、U2006218);北京市自然科学基金项目(No.2214057);北京市教育委员会科研计划项目(KM202111232005);北京市属高等学校高水平科研创新团队建设支持计划项目(BPHR20220124)资助。

摘　　要：随着社会经济的快速发展和人民生活水平的不断提高,医疗健康已具有重要的战略地位。生物传感技术作为一种重要分析检测手段,在医疗健康领域发挥着关键作用。压电生物传感器是利用压电材料进行生物分析的一种新型生物传感器,具有稳定性好、检测速度快、精确度高、操作简单的优良特性,在生物医学、健康监护和疾病防控等领域具有重要的应用价值。本文综述了近年来国内外压电生物传感器的研究进展,介绍了基于石英晶体微天平压电效应的压电生物传感器的工作原理及常用的压电材料,包括无机压电材料、有机压电材料、压电复合材料以及生物压电材料。此外,还介绍了压电生物传感器在人体健康监护与疾病防控方面的应用,如心率、脉搏等生理性体征的监测,生物标志物及新冠肺炎等流行病毒的检测。最后总结了目前压电生物传感器面临的问题,并对其未来的发展进行了展望。With the rapid development of social economy and the continuous improvement of people's living standards,medical and health care have taken on an important strategic position.As an important analytical detection method,biosensing technology plays a key role in the field of medical health.Piezoelectric biosensor,as a new kind of biosensor,utilizes piezoelectric materials for biological analysis.Piezoelectric biosensor has the advantages of good stability,fast detection speed,high accuracy and simple operation,and has important application value in biomedicine,health monitoring and disease prevention and control.Herein,we review the research progress of piezoelectric biosensor home and abroad in recent years,and introduce the principle of piezoelectric biosensors based on the piezoelectric effect of quartz crystal microbalance and the commonly used piezoelectric materials,including inorganic piezoelectric materials,organic piezoelectric materials,piezoelectric composite materials and biological piezoelectric materials.In addition,the applications of piezoelectric biosensors in human health monitoring and disease prevention and control are also introduced,such as the monitoring of physiological signs,such as heart rate,blood pressure and pulse,the detection of biomarkers and epidemic viruses such as SARS-CoV-2(COVID-19).Finally,the current problems faced by piezoelectric biosensors are summarized,and the future development of piezoelectric biosensors is prospected.

关 键 词：生物传感 压电材料 生物标志物 疾病防控 压电效应 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]