4-单取代-1,2,3-三氮唑的合成研究  

Synthesis of 4-Monosubstituted 1,2,3-Triazoles

作　　者：滕丽果 张水滔 肖铁波 杨保民[1] 江玉波[1] Liguo Teng;Shuitao Zhang;Tiebo Xiao;Baomin Yang;Yubo Jiang(Faculty of Science,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学理学院,昆明650500

出　　处：《化学进展》2024年第7期1014-1025,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21662020)资助。

摘　　要：1,2,3-三氮唑是一类具有独特生物学及材料学特性的五元氮杂环化合物。自2002年Sharpless及Meldal等发展的铜催化叠氮-炔偶极环加成反应以来,该类化合物在医药、农药及材料等领域发挥着越来越重要的作用。4-单取代-1,2,3-三氮唑是该类化合物家族中的重要成员之一,并具有易于修饰转化的结构优点,其合成具有重要的研究价值。本文综述了该类化合物的合成进展:按反应类型及底物特点进行分类,主要包括炔烃-叠氮化物环加成、硝基烯烃-叠氮化物环加成、腙与氨衍生物的环化、1,4-二取代-1,2,3-三氮唑去取代基等,分别讨论了底物范围、局限性、优势以及部分反应机理,并对该领域未来发展趋势进行了展望。1,2,3-Triazoles are a kind of five-membered N-heterocycles featured with unique properties in biology and material science.They have played more and more important roles in the fields of medicine,pesticide,and materials since the Cu-catalyzed diploar cycloaddition reaction of azide and alkyne was founded by Sharpless and Medal groups,respectively.4-Monosubstituted 1,2,3-triazole is considerably important in its family,especially because of its structural merits of widely facile modifications.The synthesis of 4-monosubstituted 1,2,3-triazoles based on different reaction types and substrates,including cycloaddition of alkyne with azide,cycloaddition of nitroolefin with azide,cyclization of hydrazone with amino derivatives,and N^(1)-substituent removal of 1,4-disubstituted 1,2,3-triazoles are reviewed.The substrate scope,limitation,and representative mechanism are also discussed.

关 键 词：4-单取代-1 2 3-三氮唑 合成 环加成 环化 去取代基 

分 类 号：O626.26[理学—有机化学]