代谢综合征及其组分与脑卒中发病关系的前瞻性队列研究  

A prospective cohort study on the relationship between metabolic syndrome and its components and the incidence of stroke

作　　者：孔晓玲 史宏 潘英姿[1] 许敏锐[1] 石素逸[1] 宗菁 闫于飘 杨佳成 张锡炳 杭栋[2] 刘逸舒 强德仁[1] KONG Xiaoling;SHI Hong;PAN Yingzi;XU Minrui;SHI Suyi;ZONG Jing;YAN Yupiao;YANG Jiacheng;ZHANG Xibing;HANG Dong;LIU Yishu;QIANG Deren(Department of Chronic Disease,Wujin District Center for Disease Control and Prevention,Changzhou 213164;School of Public Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]常州市武进区疾病预防控制中心慢病科,江苏常州213164 [2]南京医科大学公共卫生学院,江苏南京211166

出　　处：《南京医科大学学报（自然科学版）》2024年第9期1238-1245,共8页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省预防医学科研课题面上项目(Ym2023014);2021年度常州市卫健委科技项目(青年人才科技项目(QN202141));常州市卫健委科技项目(QN202382);2022年武进区科技创新发展专项资金;南京医科大学常州公共卫生高等研究院开放课题(CPHN202303)。

摘　　要：目的:探讨代谢综合征(metabolic syndrome,MS)及其组分与脑卒中发病风险的关联。方法:采用前瞻性队列研究方法比较脑卒中发病与未发病人群人口统计学信息、行为生活方式、饮食习惯、疾病史、MS相关指标之间差异。采用Cox比例风险回归模型分析MS组分及其交互作用与脑卒中发病的关联。结果:脑卒中发病人群的年龄、腰围(waist circumference,WC)、体重指数(body mass index,BMI)、血压(blood pressure,BP)、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、空腹血糖(fasting plasma glucose,FPG)值均高于未发病人群。校正混杂因素后,MS、WC、TG、BP、FPG均与脑卒中发病风险增加相关,其中BP异常与脑卒中发病的联系最强。WC、TG、BP、FPG两两之间均不存在相乘交互作用及相加交互作用。结论:MS与脑卒中发病风险增加相关。WC、TG、BP和FPG是脑卒中发病的独立危险因素。BP异常对脑卒中发病的影响最大。Objective:To investigate the association between metabolic syndrome(MS)and its components with the risk of stroke incidence.Methods:A prospective cohort study was conducted to compare the differences in demographic information,behavioral lifestyle,dietary habits,medical history,and MS-related indicators between people with and without stroke.The Cox proportional hazards regression analysis model was used to analyze the association between MS components,their interactions,and the incidence of stroke.Results:Stroke patients had higher age,waist circumference(WC),body mass index(BMI),blood pressure(BP),total cholesterol(TC),triglycerides(TG),and fasting plasma glucose(FPG)compared to non-stroke patients.After adjusting for confounding factors,MS,WC,TG,BP,and FPG were all associated with an increased risk of stroke,with abnormal BP showing the strongest association with stroke incidence.There were no multiplicative interaction or additive interactions between WC,TG,BP,and FPG.Conclusion:MS is associated with an increased risk of stroke incidence.WC,TG,BP,and FPG independently contribute to stroke risk,with abnormal BP exerting the greatest impact on stroke incidence.

关 键 词：脑卒中 代谢综合征 队列研究 交互作用 

分 类 号：R589[医药卫生—内分泌] R743[医药卫生—内科学]