肾移植与人体微生态的相关性研究进展  

Progress in understanding of correlation between kidney transplantation and human microecology

作　　者：张秋玥 程羽 牛雨田 唐茂芝 张克勤 张懿 郭亚楠[1] 涂增[3] Qiuyue Zhang;Yu Cheng;Yutian Niu;Maozhi Tang;Keqin Zhang;Yi Zhang;Yanan Guo;Zeng Tu(International Medical College,Chongqing Medical University,Chongqing 401331,China;Urinary Nephropathy Center,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;College of Basic Medical Sciences,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学国际医学院,重庆401331 [2]重庆医科大学附属第二医院泌尿肾病中心,重庆400010 [3]重庆医科大学基础医学院,重庆400016

出　　处：《中华临床医师杂志（电子版）》2024年第2期207-213,共7页Chinese Journal of Clinicians(Electronic Edition)

基　　金：重庆市自然科学基金(cstc2021jcyj-msxmX0158);重庆市高等教育教学改革研究项目(223115);重庆医科大学2021年校级教育教学研究项目(JY210301,JY210336)。

摘　　要：肾移植是终末期肾病或终末期肾衰竭患者的首选治疗方式。防治肾移植术后并发症,提高移植肾存活率是值得持续关注的话题。近年来,研究人员对肾移植与人体微生态的相关性进行了大量研究。肾移植会导致人体微生物群构成和丰度的改变,进而对肾移植结局产生影响。该影响涉及术后免疫排斥、感染、腹泻和移植肾功能变化等。研究肾移植后人体微生物群的变化,针对特定微生物群的处理,可有效预测肾移植结局,并有效预防肾移植术后并发症,维护好移植肾功能。本文系统性的总结了目前肾移植和人体微生物群的相关研究,以期为改善肾移植结局提供新的方向和参考。Kidney transplantation is the optimal treatment for patients with end-stage renal failure.Preventing complications and improving the survival of the transplanted kidney are important issues which deserve constant attention.In recent years,researchers have conducted numerous studies on the correlation between kidney transplantation and human microecology.Kidney transplantation can lead to the change of the human microbiota,which may in turn affect the renal transplantation outcome,including postoperative allograft rejection,infection,diarrhea,and delayed graft function.Studying the alteration of human microbiota composition may effectively predict the outcome of kidney transplantation.And the intervention of a specific microbiota can help to prevent the post-transplanting complication and maintain the graft function.This article systematically summarizes current studies on kidney transplantation and human microbiota,with an aim to provide a new direction and reference for improving the outcome of kidney transplantation.

关 键 词：肾移植 人体微生态 免疫排斥 感染 菌群失调 

分 类 号：R699.2[医药卫生—泌尿科学]