嗜酸性环形红斑1例  

Eosinophilic Annular Erythema:A Case Report

作　　者：杨逸轩 王俊慧[1] 万祖霖 崔炳南[1] 孔倩[1] YANG Yixuan;WANG Junhui;WAN Zulin;CUI Bingnan;KONG Qian(Department of Dermatology,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院皮肤科,北京100053

出　　处：《中国皮肤性病学杂志》2024年第9期1029-1032,共4页The Chinese Journal of Dermatovenereology

基　　金：首都国医名师许铣学术思想及临床经验传承研究(HLCMHPP2023025);国家中医临床研究示范基地科研专项暨所级科研基金课题(2019S457)。

摘　　要：患者女,28岁,躯干和下肢反复出现环形红斑3年。皮肤科情况:腹部、腰臀部、下肢多发浮肿性红斑,部分中央消退,消退后遗留色素沉着,边缘隆起,呈环形、半环形,躯干、下肢可见色素沉着。皮损组织病理示:表皮角化过度,轻度增生,真皮浅中层毛细血管增生扩张,血管周围可见淋巴细胞及大量嗜酸性粒细胞浸润,部分嗜酸性粒细胞可见脱颗粒现象,真皮中下层胶原增生硬化。诊断:嗜酸性环形红斑。以清热利湿,活血通络中药汤药口服,治疗近半年,皮损基本消退。目前患者仍在继续随访中。A 28-year-old female patient had been experiencing recurrent annular erythema on her trunk and lower extremities for three years.Dermatological examination revealed multiple edematous and erythematous plaques distributed across the abdomen,waist,buttocks,and lower extremities.These plaques exhibited partial central regression,leaving behind pigmentation,and raised borders,presenting in an annular or semi-annular pattern.Associated pigmentation was also observed on the trunk and lower extremities.Histopathological examination of the lesions demonstrated hyperkeratosis and mild hyperplasia in the epidermis.Additionally,there was capillary dilatation in the superficial and middle layers of the dermis.A perivascular infiltrate consisting of lymphocytes and a significant number of eosinophils was observed.Notably,some of the eosinophils exhibited a degranulation phenomenon.Furthermore,collagen hyperplasia and sclerosis were evident in the middle and lower layers of the dermis.Based on these findings,a diagnosis of eosinophilic annular erythema was made.After oral administration of traditional Chinese medicine soup for nearly half a year,which aims to clear heat and dampness,promote blood circulation,and unblock meridians,the skin lesions had basically subsided.The patient was currently under follow-up observation.

关 键 词：环形红斑 嗜酸性粒细胞 

分 类 号：R758.61[医药卫生—皮肤病学与性病学]