抗结核药物诱导银屑病消退及斑秃发生1例  

Anti-Tuberculosis Drug Induced Regression of Psoriasis and Occurrence of Alopecia Areata:A Case Report

作　　者：李孟桓 吴蔚[1,2] 马红[1,2] 张翰林 张烨 李遇梅[1,2] 刘莉萍[1,2] LI Menghuan;WU Wei;MA Hong;ZHANG Hanlin;ZHANG Ye;LI Yumei;LIU Liping(Department of Dermatology,the Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China;Institute of Regenerative Medicine,Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院皮肤科,江苏镇江212001 [2]江苏大学再生医学研究院,江苏镇江212001

出　　处：《中国皮肤性病学杂志》2024年第9期1033-1036,共4页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(82103766);江苏省医学重点学科建设单位项目(JSDW202229)。

摘　　要：患者男,64岁,弥漫性斑片状脱发1个月。患者有中重度斑块型银屑病病史17年,在使用利福平和异烟肼进行预防性抗结核治疗中,银屑病皮损出现显著缓解,但发生了弥漫性斑片状脱发。在停用抗结核药物和给予肌注及外用糖皮质激素治疗后,斑秃逐渐缓解,但银屑病皮损再次复发,这表明抗结核药物可能通过多个关键因子发挥抗炎和免疫调节作用。A 64-year-old man presented with diffuse patchy alopecia for one month.He had a 17-year history of moderate to severe plaque psoriasis.Significant resolution of psoriasis lesions occurred during preventive anti-tuberculosis therapy using isoniazid and rifampicin.However,diffuse patchy alopecia areata developed.After withdrawal of anti-tuberculosis drugs and administration of glucocorticoids,alopecia areata was in remission gradually.However,psoriatic lesions returned.Anti-tuberculosis drugs may exert anti-inflammatory and immunomodulatory effects through multiple key factors.

关 键 词：银屑病 斑秃 利福平 异烟肼 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R758.71[医药卫生—临床医学]