黏液水肿性苔藓1例  

Lichen Myxedematosus:A Case Report

作　　者：丁文媛 吕新翔[1] 李东霞[1] 韩建文[1] 刘玉磊[1] 李欣[1] 孙志强[1] 吴美乐 贺伟[1] DING Wenyuan;LYU Xinxiang;LI Dongxia;HAN Jianwen;LIU Yulei;LI Xin;SUN Zhiqiang;WU Meile;HE Wei(Department of Dermatology and Venereology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院皮肤性病科,内蒙古呼和浩特010050

出　　处：《中国皮肤性病学杂志》2024年第9期1043-1046,共4页The Chinese Journal of Dermatovenereology

基　　金：内蒙古医科大学青年创新基金项目(YKD2018QNCX057)。

摘　　要：患者女,53岁,8年前首次因躯干四肢丘疹、硬化伴瘙痒20 d就诊。皮肤科情况:额头、面部、前胸、后背、双臂延及双手可见多形性扁平肤色或橘黄色小丘疹,丘疹表面蜡样光泽,质地较硬,圆顶形或平顶形,丘疹和结节可融合形成斑块,丘疹呈线性排列,局部形成较深的沟纹。左腹部皮损组织病理示:表皮大致正常,真皮上部网状层见间质性黏蛋白、成纤维细胞和胶原蛋白增加。诊断:黏液水肿性苔藓。自行停用硫酸羟氯喹及糖皮质激素后,自我心理疏导,皮疹逐渐消退,随访8年未见复发。A 53-year-old female initially presented 8 years ago with papules,hardening,and itching on her trunk and limbs that had been present for 20 d.The dermatological condition presented as multiple waxy,small,round papules ranging from skin-colored to orange were observed on the patient′s forehead,face,front chest,back,and bilateral arms extending to her hands.The papules exhibited a waxy surface,which were firm,and dome-shaped or flat-topped.The papules and nodules could coalesce to form plaques,and the papules were commonly arranged in a linear pattern,with deep grooves formed locally.Histopathology of the skin lesions on the left abdomen revealed generally normal epidermis,with interstitial mucin,increased fibroblasts,and collagen in the upper reticular dermis.The diagnosis was lichen myxedematosus.After discontinuing glucocorticoid and hydroxychloroquine sulfate,the patient engaged in self-psychological care.Subsequently,the rash gradually subsided,and there has been no recurrence during the 8-year follow-up.

关 键 词：黏液水肿性苔藓 糖皮质激素 硫酸羟氯喹 静脉注射丙种球蛋白 IL-4抑制剂 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]