α干扰素栓联合二氧化碳激光治疗尖锐湿疣患者的效果  

Effects of interferonαsuppository combined with Carbon dioxide laser in treatment of patients with condyloma acuminatum

作　　者：董珂 高昀 周彩风 DONG Ke;GAO Yun;ZHOU Caifeng(Mianchi County People’s Hospital,Department of Dermatology,Sanmenxia 472400 Henan,China;Mianchi County People’s Hospital,Department of Endocrinology,Sanmenxia 472400 Henan,China)

机构地区：[1]渑池县人民医院皮肤科,河南三门峡472400 [2]渑池县人民医院内分泌科,河南三门峡472400

出　　处：《中国民康医学》2024年第17期47-50,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察α干扰素栓联合二氧化碳激光治疗尖锐湿疣患者的效果。方法:选取2021年5月至2023年5月该院收治的100例尖锐湿疣患者进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各50例。对照组采用二氧化碳激光治疗,研究组在对照组基础上联合α干扰素栓治疗。比较两组临床疗效,治疗前后炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)]、T细胞亚群指标(CD3+、CD4+、CD8+)水平,不良反应发生率和复发率。结果:研究组治疗总有效率为96.00%,高于对照组的84.00%,差异有统计学意义(P<0.05);治疗后,两组PCT、IL-6、CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组CD3+、CD4++水平均高于治疗前,且研究组高于对照组,两组CD8水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论:α干扰素栓联合二氧化碳激光治疗尖锐湿疣患者可提高临床疗效,改善T细胞亚群指标水平,降低炎性因子水平和复发率,其效果优于单纯二氧化碳激光治疗。Objective:To observe effects of interferonαsuppository combined with Carbon dioxide laser in treatment of patients with condyloma acuminatum.Methods:A prospective study was conducted on 100 patients with condyloma acuminatum admitted to this hospital from May 2021 to May 2023.According to the random number table method,they were divided into study group and control group,50 cases in each group.The control group was treated with Carbon dioxide laser,while the study group was treated with Interferonαsuppository on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)]and T cell subsets indexes(CD3+,CD4+,CD8+)before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.00%,which was higher than 84.00%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PCT,IL-6 and CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD3+and CD4+in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of CD8+in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusions:Interferonαsuppository combined with Carbon dioxide laser in the treatment of the patients with condyloma acuminatum can improve the clinical efficacy,impro

关 键 词：α干扰素栓 二氧化碳激光治疗 尖锐湿疣 炎性因子 T细胞亚群指标 复发率 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]