辐照血小板保存时间对输血反应的影响  

The Effect of Irradiation Platelet Preservation Time on Transfusion Re⁃sponse

作　　者：李继东[1] 夏和凤[1] 韩霜[1] 袁圆 李婷 纪蓉 LI Jidong;XIA Hefeng;HAN Shuang;YUAN Yuan;LI Ting;JI Rong(Department of Blood Transfusion,Dongtai People's Hospital,Dongtai 224200,Jiangsu,China)

机构地区：[1]东台市人民医院输血科,江苏东台224200

出　　处：《中外医疗》2024年第22期32-35,共4页China & Foreign Medical Treatment

基　　金：江苏医药职业学院临床教学医院专项科研课题(20229DT15)。

摘　　要：目的研究辐照血小板保存时间对输血反应发生率的影响。方法方便选择2020年1月—2023年8月东台市人民医院输血的105例血液病患者为研究对象,根据不同保存时间分组,n1组(35例)保存时间1 d,n2组(35例)保存时间3 d,n3组(35例)保存时间5 d,比较3组患者输血后的有效率、不良反应发生率,输血前、后免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白A(immuno-globulin A,IgA)、C反应蛋白(C-reactive protein,CRP)的变化。结果n1组输血后的有效率为90.77%(59/65),高于n2组的84.13%(53/63)和n3组的74.60%(47/63),差异有统计学意义(χ^(2)=1.764,P<0.05)。n1组不良反应发生率为5.71%(2/35),低于n2组的14.29%(5/35)和n3组的22.86%(8/35),差异有统计学意义(χ^(2)=4.201,P<0.05)。输血前,3组IgG、IgM、IgA、CRP对比,差异无统计学意义(P均>0.05),输血后,3组IgG、IgM、IgA、CRP均高于输血前,差异有统计学意义(P均<0.05);3组免疫及炎症反应对比,差异无统计学意义(P>0.05)。结论输注辐照血小板在保存期内,储存时间越短,效果越好,输血反应的发生率越低。Objective To investigate the effect of irradiation platelet preservation time on the incidence of transfusion reactions.Methods A total of 105 patients with blood diseases who were transfused in Dongtai People's Hospital from January 2020 to August 2023 were conveniently selected as the study subjects.According to different preservation times,the preservation time of n1 group(35 cases)preservation time was 1 day,that of n2 group(35 cases)preservation time was 3 days,and that of n3 group(35 cases)was 5 days.The effective rate,incidence of adverse reactions,and changes in immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)and C-reactive protein(CRP)of the 3 groups were compared before and after transfusion.Results The effective rate of n1 group was 90.77%(59/65),which was higher than that of n2 group 84.13%(53/63)and n3 group 74.60%(47/63),and the difference was statistically significant(χ^(2)=1.764,P<0.05).The incidence of adverse reactions in n1 group was 5.71%(2/35),which was lower than 14.29%(5/35)in n2 group and 22.86%(8/35)in n3 group,and the difference was statistically significant(χ^(2)=4.201,P<0.05).Before blood transfusion,there was no statistically significant difference in IgG,IgM,IgA,CRP among the 3 groups(all P>0.05);after blood transfusion,IgG,IgM,IgA,CRP among the 3 groups were higher than before blood transfusion,the differences were statistically significant(all P<0.05).There was no significant difference in immune and inflammatory response among the three groups(P>0.05).Conclusion During the preservation period,the shorter the storage time,the better the effect and the lower the incidence of transfusion reaction.

关 键 词：辐照血小板 保存时间 输血反应 治疗效果 免疫球蛋白 

分 类 号：R4[医药卫生—临床医学]