小剂量胰岛素微泵泵入对急诊酮症酸中毒糖尿病患者急救效果的影响  

Effects of Low-dose Insulin Pump on the First-aid Effect of Diabetic Pa⁃tients with Ketoacidosis in Emergency Department

作　　者：白杨 赵文杰 孙佳慧 BAI Yang;ZHAO Wenjie;SUN Jiahui(Department of Emergency Medicine,Second Affiliated Hospital of Mudanjiang Medical College,Mudanjiang 157000,Heilongjiang,China;Department of Internal Medicine,Second Affiliated Hospital of Mudanjiang Medical College,Mudanjiang 157000,Heilongjiang,China;Department of Endocrinology,Second Affiliated Hospital of Mu-danjiang Medical College,Mudanjiang 157000,Heilongjiang,China)

机构地区：[1]牡丹江医学院附属第二医院急诊科,黑龙江牡丹江157000 [2]牡丹江医学院附属第二医院内科,黑龙江牡丹江157000 [3]牡丹江医学院附属第二医院内分泌科,黑龙江牡丹江157000

出　　处：《中外医疗》2024年第22期63-66,共4页China & Foreign Medical Treatment

摘　　要：目的探析小剂量胰岛素微泵泵入治疗方案用于急诊糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)患者急救的效果及影响。方法随机选取2021年6月—2023年6月牡丹江医学院附属第二医院急诊科收治的80例DKA患者为研究对象,按照不同治疗方法分为对照组和观察组,每组40例。对照组给予胰岛素持续静脉滴注治疗,观察组给予小剂量胰岛素微泵泵入治疗。对比两组患者治疗相关指标水平、治疗总有效率、血糖水平、氧化应激指标水平、并发症发生情况。结果治疗后,观察组治疗相关指标低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为97.50%(39/40),高于对照组的85.00%(34/40),差异有统计学意义(χ^(2)=3.914,P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组丙二醛水平低于对照组,超氧化物歧化酶、谷胱甘肽过氧化物酶均高于对照组,差异有统计学意义(P均<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论对急诊DKA患者实施小剂量胰岛素微泵泵入治疗作用显著,可改善临床治疗指标,减少并发症的发生,安全性较高。Objective To explore the effects of low-dose insulin pump for emergency treatment of patients with emergency Diabetic Ketoacidosis(DKA).Methods A total of 80 DKA patients admitted to the Emergency Department of the Second Affiliated Hospital of Mudanjiang Medical College from June 2021 to June 2023 were randomly selected as the study objects,and were divided into control group and observation group according to the different treatment methods,with 40 cases in each group.The control group was given continuous intravenous infusion of insulin,and the observation group was given low-dose insulin pump.The treatment-related indicators level,total effective rate,blood glucose level,oxidative stress indicators level,and complications were compared between the two groups.Results After treatment,the treatment related indexes in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 97.50%(39/40),which was higher than that of the control group 85.00%(34/40),and the difference was statistically significant(χ^(2)=3.914,P<0.05).After treatment,the fasting blood glucose and 2 h postprandial blood glucose in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the malondialdehyde level in observation group was lower than that in control group,superoxide dismutase and glutathione peroxidase were higher than those in control group,and the differences were statistically significant(all P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The effect of low-dose insulin pump in emergency DKA patients is significant,which can improve clinical therapeutic indexes,reduce the occurrence of complications,and has high safety.

关 键 词：糖尿病 胰岛素微泵 急救效果 酮症酸中毒 

分 类 号：R249[医药卫生—中医临床基础]