加味涤痰汤联合桃红四物汤在痰瘀阻络型脑梗死患者中的应用效果及对患者神经功能、氧化应激状况的影响研究  

Application of Modified Ditan Decoction and Taohong Siwu Decoction in Patients with Cerebral Infarction of Phlegm-stasis Blocking Type and Its Effect on Neurological Function and Oxidative Stress

作　　者：刘佳静 陈辉 林艳清 LIU Jiajing;CHEN Hui;LIN Yanqing(Department of Traditional Chinese Medicine Neurology(Department of Encephalopathy),Affiliated People's Hospi-tal of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,Fujian,China;Acupuncture and Moxibus-tion Department of Fujian Provincial Rehabilitation Hospital,Fuzhou 350003,Fujian,China)

机构地区：[1]福建中医药大学附属人民医院中医神经内科(脑病科),福建福州350004 [2]福建省康复医院针灸科,福建福州350003

出　　处：《中外医疗》2024年第22期190-193,198,共5页China & Foreign Medical Treatment

基　　金：福建省中医药科研项目(202lzylc36)。

摘　　要：目的探讨加味涤痰汤联合桃红四物汤在痰瘀阻络型脑梗死患者中的应用及对患者神经功能、氧化应激状况的影响。方法前瞻性随机选取2021年1月—2023年12月福建中医药大学附属人民医院收治的106例痰瘀阻络型脑梗死患者为研究对象,根据不同治疗方法分为观察组和对照组,每组53例。对照组行复方地龙片治疗,观察组行加味涤痰汤联合桃红四物汤治疗,比较两组患者的治疗总有效率、证候积分、神经功能以及氧化应激水平。结果观察组治疗总有效率[94.34%(50/53)]较对照组[81.13%(43/53)]更高,差异有统计学意义(χ^(2)=4.296,P=0.038)。治疗后,观察组的证候积分各指标(主症、次症及总分)较对照组均更低,差异有统计学意义(P均<0.05)。治疗后,观察组的神经功能缺损状况得分较对照组更低,差异有统计学意义(P<0.05)。治疗后,观察组超氧化物歧化酶较对照组更高,丙二醛及晚期氧化蛋白产物较对照组更低,差异有统计学意义(P均<0.05)。结论加味涤痰汤联合桃红四物汤能够提升痰瘀阻络型脑梗死患者的用药疗效,加快缓解中医证候,改善神经功能及机体氧化应激状况。Objective To investigate the application of Jiawei Ditan Decoction combined with Taohong Siwu Decoction in patients with cerebral infarction of phlegm and blood stasis type and its effect on neurological function and oxidative stress.Methods From January 2021 to December 2023,106 patients with cerebral infarction of phlegm and blood stasis type admitted to the People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine were prospective randomly selected and divided into observation group and control group by different treatment methods,53 cases in each group.The control group was treated with Fufang Dilong tablets,and the observation group was treated with modified Ditan decoction combined with Taohong Siwu decoction.The total effective rate,syndrome score,neurological function and oxidative stress level were compared between the two groups.Results The total effective rate of the observation group[94.34%(50/53)]was higher than that of the control group[81.13%(43/53)],and the difference was statistically significant(χ^(2)=4.296,P=0.038).After treatment,the indexes of syndrome scores(main symptoms,secondary symptoms and total scores)in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the neurological deficit score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the superoxide dismutase in the observation group was higher than that in the control group,and the malondialdehyde and advanced oxidation protein products were lower than those in the control group,the differences were statistically significant(all P<0.05).Conclusion Modified Ditan Decoction combined with Taohong Siwu Decoction can improve the efficacy of patients with cerebral infarction of phlegm-stasis blocking type,accelerate the relief of traditional Chinese medicine syndromes,and improve neurological function and oxidative stress.

关 键 词：脑梗死 加味涤痰汤 桃红四物汤 神经功能 氧化应激状况 

分 类 号：R5[医药卫生—内科学]